Source: Annual Congress 2002 - Cellular reactions in allergy in humans and animals
Disease area: Airway diseases

Abstract

Hepatocyte growth factor (HGF) is recognized as a humoral mediator of epithelial-mesenchymal interactions in tissue regeneration and recent studies have reported that HGF prevents lung fibrosis as well as fulminant hepatic failure and liver cirrhosis. In this study, we investigated the in vivo effects of recombinant human HGF in a murine model of asthma. After ovalbumin (OVA) sensitization and airway challenge, airway function was monitored by changes enhanced pause (Penh) to inhaled methacholine. Following OVA challenge, Penh significantly increased as did the number of lung inflammatory cells and IL-5 and IL-13 levels in bronchoalveolar lavage fluid (BALF) (p<0.05). Administration of HGF during OVA challenge significantly prevented changes in Penh and goblet cell hyperplasia as well as eosinophil numbers and IL-5 and IL-13 levels in BALF (p<0.05). These data indicate that HGF plays an important role in the development of asthma and treatment with HGF may be considered as a new therapeutic strategy for allergic diseases.

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W. Ito, A. Kanehiro, S. Yuzurio, K. Matsumoto, T. Nakamura, M. Tanimoto (Okayama, Osaka, Japan). Hepatocyte growth factor attenuates airway hyperresponsiveness and airway inflammation in a murine model of asthma. Eur Respir J 2002; 20: Suppl. 38, 296

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