Source: Annual Congress 2002 - Epidemiology outlooks of tuberculosis
Disease area: Respiratory infections

Abstract

To determine trends in tuberculosis case fatality in England and Wales according to age and disease site, we analysed published data on notifications and deaths from tuberculosis from 1988 to 2000 (table). Case fatality for tuberculosis of all sites and age groups combined has fallen over this period; this trend is most marked for respiratory disease, and in the 35-74 age-group. Falling case-fatality rates may reflect improvements in case-management. They might also be explained by the decreasing proportion of patients in older age-groups and with respiratory and central nervous system tuberculosis, who experience higher case-fatality rates than younger patients with disease elsewhere.

Year	Respiratory	CNS	Other Site	Age 0-34	Age 35-74	Age >74	Total
1988	9.55	17.80	7.21	0.42	10.10	36.94	9.26
1989	8.03	42.30	6.90	0.69	8.15	34.95	8.15
1990	7.94	16.00	5.21	0.69	7.80	29.97	7.49
1991	8.45	8.20	5.48	0.57	7.81	40.6	7.76
1992	7.35	16.85	6.25	0.67	7.61	31.14	7.21
1993	7.14	9.09	6.99	0.71	7.75	30.02	7.14
1994	7.74	13.00	6.29	0.77	8.39	28.84	7.48
1995	8.56	9.18	6.14	1.03	8.47	32.33	7.97
1996	7.46	12.39	6.63	0.56	7.85	30.87	7.36
1997	6.52	11.02	6.35	0.57	6.96	29.08	6.57
1998	6.36	9.16	6.45	0.89	6.76	30.43	6.44
1999	6.87	4.92	4.68	0.59	6.13	30.68	6.23
2000	5.78	7.45	5.08	0.60	5.64	29.46	5.63

Case-fatality rate (per 100 cases) for tuberculosis of the respiratory system, central nervous system (CNS) and other sites, and for tuberculosis of all sites combined for age groups 0-34 years, 35-74 years, over 74 years and all ages combined, England and Wales, 1988-2000.

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Citations should be made in the following way:
A. R. Martineau, P. D. O. Davies (London, Liverpool, United Kingdom). Trends in tuberculosis case fatality in England and Wales 1988-2000. Eur Respir J 2002; 20: Suppl. 38, 272

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