Source: Annual Congress 2002 - Effects of air pollution on lung cells
Disease area: Airway diseases

Abstract

Diesel exhaust (DE) is a major source of particulate matter (PM) pollution. Epidemiological data suggest asthmatics to be a sensitive group with respect to air pollution.
This study was performed to compare the airway inflammatory responses of subjects with asthma with (n=14) and without inhaled corticosteroids (ICS)(n=16) to that of healthy (n=24), when exposed to DE (PM₁₀ 100mg/m³) and air for 2 hours. Bronchoscopy with bronchial wash (BW) and bronchoalveolar lavage (BAL) was performed at 18 hours.
At baseline, asthmatics had sign. higher BW-eosinophils (p=0.015) and mast cells (p=0.001) vs. healthy.
In healthy, DE induced a neutrophilic airway inflammation in BW (p<0.01). In asthmatics without ICS, DE induced an increase in BAL-mast cell % (p=0.03) and decreased eosinophils (p=0.06). Asthmatics on ICS showed no sign. airway inflammatory changes after DE.
The DE induced responses, relative to the air responses, showed sign. higher % of BW-neutrophils in healthy compared to asthmatics without ICS(p=0.027), but no change compared to asthmatics with ICS. BAL-mast cell % after DE, relative to air exposure, were higher in the non-ICS treated group (p<0.01), whereas the ICS treated group of asthmatics showed no sign. changes.
In summary, DE exposure induced different responses in healthy and asthmatic subjects with and without inhaled corticosteroids. Healthy presented a neutrophilic inflammation and asthmatics without ICS showed a mastcell dominated inflammation. The data may suggest a protective effect against DE-induced airway inflammation by the inhaled corticosteroid treatment.

Rating:

Share or cite this content

Citations should be made in the following way:
A. F. Behndig, J. Brown, A. J. Frew, R. Helleday, F. J. Kelly, J. Pourazar, N. Stenfors, T. Sandström, A. Blomberg (Umeå, Sweden; Southampton, London, United Kingdom). Diverging airway inflammatory responses to diesel exhaust exposure in healthy and asthmatic subjects with and without inhaled corticosteroid treatment. Eur Respir J 2002; 20: Suppl. 38, 264

Member's Comments

No comment yet.

Related content which might interest you: Different airway inflammatory responses in asthmatic and healthy humans exposed to diesel Source: Eur Respir J 2004; 23: 82-86 Year: 2004 Diesel exhaust enhances airway responsiveness in asthmatic subjects Source: Eur Respir J 2001; 17: 909-915 Year: 2001 Evaluation of diesel exhaust exposure on systemic inflammatory and coagulation markers in asthmatic subjects Source: Annual Congress 2004 - Particle effects on humans Year: 2004 Effect of IgE sensitization and allergen exposure on exhaled NO during inhaled corticosteroid (ICS) treatment in patients with asthma Source: Annual Congress 2007 - Primary care respiratory problems Year: 2007 Small airway function in asthma patients treated with an ultrafine inhaled steroid aerosol Source: Eur Respir J 2004; 24: Suppl. 48, 581s Year: 2004 IL-13 expression in the bronchial epithelium of healthy non-atopic subjects is enhanced by diesel exhaust exposure Source: Eur Respir J 2002; 20: Suppl. 38, 132s Year: 2002 Bronchodilator effect of deep inhalation, airway inflammation, and allergen avoidance in asthmatic children Source: Eur Respir J 2003; 22: Suppl. 45, 383s Year: 2003 Respiratory effects of exposure to diesel exhaust in subjects with asthma Source: Annual Congress 2009 - Indoor and outdoor air pollution Year: 2009 Inhaled diesel exhaust alters the allergen-induced bronchial secretome in humans Source: Eur Respir J, 51 (1) 1701385; 10.1183/13993003.01385-2017 Year: 2018 Low dose diesel exhaust particle exposure exacerbates allergic asthma in young mice Source: Annual Congress 2012 - Mechanisms and modulation of allergic inflammation in the lung Year: 2012 Salmeterol has no effect on increased bronchial responsiveness induced by organic dust exposure in healthy volunteers Source: Eur Respir J 2003; 22: Suppl. 45, 286s Year: 2003 Short-term treatment with sistemic corticosteroids blunted neutrophilic airway response to ozone in mild asthmatics Source: Eur Respir J 2002; 20: Suppl. 38, 569s Year: 2002 Assessing small airways dysfunction in asthma, asthma remission and healthy controls using particles in exhaled air Source: ERJ Open Res, 5 (4) 00202-2019; 10.1183/23120541.00202-2019 Year: 2019 The effects of inhaled acid aerosol on lung function of asthmatic children Source: Eur Respir J 2003; 22: Suppl. 45, 497s Year: 2003 The effects of two weeks of repeated low-dose allergen exposure on sputum eosinophilic and neutrophilic inflammation in atopic asthma: protection by inhaled steroids? Source: Eur Respir J 2001; 18: Suppl. 33, 482s Year: 2001 Increased asthma medication use in association with ambient fine and ultrafine particles Source: Eur Respir J 2002; 20: 691-702 Year: 2002 Assessing regional airways responses to inhaled bronchodilators in asthmatics Source: Annual Congress 2010 - Airways mechanics in different applications Year: 2010 Effect of an inhaled alpha4-antagonist on the allergen-induced late asthmatic response in patients with mild asthma Source: Eur Respir J 2005; 26: Suppl. 49, 135s Year: 2005 Effect of NO2 on inflammatory response in subjects with asthma Source: Annual Congress 2012 - Air pollution: from the particles in town to the pollutants in the countryside Year: 2012 Comparative airway response to high- versus low-molecular weight agents in occupational asthma Source: Eur Respir J 2009; 33: 734-739 Year: 2009