Particulate matter (PM10) in London air is highly oxidising, implying a significant potential risk to respiratory health
S. T. Duggan, I. S. Mudway, T. Moreno, R. Richards, F. J. Kelly (London, Cardiff, United Kingdom)
Source: Annual Congress 2002 - Effects of air pollution on lung cells
Session: Effects of air pollution on lung cells
Session type: Oral Presentation
Number: 260
Disease area: Airway diseases
Abstract We assessed the oxidative capacity of London PM10 by examining its ability to deplete antioxidants in a synthetic model of Respiratory Tract Lining Fluid (RTLF). PM10 collected from London air was added to RTLF (200μmol/L ascorbate, urate and reduced glutathione) at 50, 100 and 150μg/ml and incubated for 4h at 37oC, pH7.4. ROFA (residual oil fly ash) and M120 (inert carbon black) were included as positive and negative controls (50μg/ml). The concentrations of AA, UA and GSH were then determined by HPLC and spectrophotometric methods. Exposure of artificial RTLF to PM10 led to a significant (P<0.05) and dose-dependent loss of ascorbate (-87.8% [50μg/ml], -94.2% [100μg/ml], -96.6% [150μg/ml]) and reduced glutathione (-51.8%, -63.5%, -78.4%). Notably at 50μg/mL losses due to PM10 were greater (P<0.05) than with ROFA (ascorbate –83.4%, -0.3% reduced-glutathione, [50μg/ml]). Neither, London PM10 nor ROFA had any impact on urate suggesting hydroxyl radical generation was not occurring. This was confirmed by the lack of protection observed by the addition of DMSO (0.5-100mM). These data indicate that London PM is more oxidizing than ROFA, a soluble and transition metal rich particle. This high oxidative potential is worrisome as it suggests that London PM10 may have considerable biological activity.
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S. T. Duggan, I. S. Mudway, T. Moreno, R. Richards, F. J. Kelly (London, Cardiff, United Kingdom). Particulate matter (PM10) in London air is highly oxidising, implying a significant potential risk to respiratory health. Eur Respir J 2002; 20: Suppl. 38, 260
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