Source: Annual Congress 2002 - Bridging the gap - lung function from infancy through childhood
Disease area: Paediatric lung diseases

Abstract

Background: Exhaled nitric oxide (NO) is a marker of airway inflammation in adults and older children. It is not known, however, if NO measured soon after birth predicts subsequent respiratory infections in infants.
Methods: In a prospective unselected birth cohort study, tidal fractional exhaled nitric oxide (FeNO) and NO output (V'NO) were measured in 40 healthy unsedated infants at the age of one month. Respiratory symptoms were assessed with weekly phone calls during the first year of life. A respiratory infection score was calculated as the number of weeks with standardised lower and upper respiratory symptomatology lasting >2 days. Multiple logistic regression was used to investigate the association between NO and infection score, adjusting for confounders.
Results: Mean (SEM) FeNO and V'NO in the infants was 17.1 (1.2) ppb and 0.67 (0.04) nl/s respectively. Median infection score was 2 (range 0-10). Adjusting for tidal breathing pattern, number of siblings, maternal smoking and month of birth, we found a significant positive association between the infection score in the first year of life and both FeNO (+0.054 , p=0.008) and V'NO (+1.3, p=0.019).
Conclusion: Exhaled NO measured after birth, before the onset of any respiratory symptom, predicts subsequent respiratory infections in the first year of life.

Rating:

Share or cite this content

Citations should be made in the following way:
C. E. Kuehni, G. L. Hall, M. Cernelc, U. Frey (Bern, Switzerland). Exhaled nitric oxide measured after birth predicts subsequent respiratory infections in infants. Eur Respir J 2002; 20: Suppl. 38, 258

Member's Comments

No comment yet.

Related content which might interest you: Is exhaled nitric oxide in newborns associated with subsequent respiratory symptoms in infancy? Source: Eur Respir J 2006; 28: Suppl. 50, 269s Year: 2006 Exhaled breath temperature and nitric oxide in assessing children with and without respiratory disease Source: Annual Congress 2011 - Biological correlates and comorbidities of childhood asthma/allergy Year: 2011 Exhaled nitric oxide and airway resistance in preschool children with and without respiratory symptoms Source: Annual Congress 2008 - Wheezing in preschool children Year: 2008 Exhaled nitric oxide levels during upper respiratory infections (URI) in young patients with rinasma Source: Eur Respir J 2001; 18: Suppl. 33, 164s Year: 2001 Exhaled nitric oxide and postnatal dexamethasone in chronically ventilator dependent, preterm infants Source: Eur Respir J 2002; 20: Suppl. 38, 532s Year: 2002 Exhaled nitric oxide in children with severe asthma Source: Annual Congress 2012 - Severe asthma and developing allergy in childhood Year: 2012 Exhaled nitric oxide distinguishes between subgroups of preschool children with respiratory symptoms Source: Annual Congress 2007 - Pathophysiology of childhood asthma: new insights Year: 2007 Exhaled nitric oxide in infants: a marker of inflammation? Source: Eur Respir Monogr 2010; 49: 56-70 Year: 2010 Exhaled nitric oxide output is decreased in preterm infants with chronic lung disease in the post-acute phase Source: Eur Respir J 2004; 24: Suppl. 48, 464s Year: 2004 Exhaled nitric oxide (eNO): an early indicator of asthma relapse in children Source: Eur Respir J 2005; 26: Suppl. 49, 42s Year: 2005 Exhaled nitric oxide and pulmonary function tests in children with asthma Source: Eur Respir J 2007; 30: Suppl. 51, 759s Year: 2007 Nasal and exhaled nitric oxide in children and adolescents with HIV-1 infection Source: Eur Respir J 2006; 28: Suppl. 50, 310s Year: 2006 Who are the children with increased faractional exhaled nitric oxide? Source: Virtual Congress 2020 – Paediatric asthma Year: 2020 Respiratory function tests and exhaled nitric oxide in asthmatic children Source: Eur Respir J 2004; 24: Suppl. 48, 270s Year: 2004 Smoke exposure, airway symptoms and exhaled nitric oxide in infants: the Generation R study Source: Eur Respir J 2008; 32: 307-313 Year: 2008 Measurement of exhaled nitric oxide in children Source: Guideline 2002 Year: 2002 Reproducibility of exhaled nitric oxide measurements in healthy and asthmatic adults and children Source: Eur Respir J 2003; 21: 433-438 Year: 2003 Exhaled nitric oxide and clinical phenotype of childhood asthma Source: Annual Congress 2011 - Inflammation and genes in childhood asthma Year: 2011 Exhaled nitric oxide measurement in obese children Source: Eur Respir J 2007; 30: Suppl. 51, 724s Year: 2007 Low exhaled nitric oxide levels in infants with respiratory symptoms in the first 2 months of life Source: Annual Congress 2006 - Markers of paediatric airway disease Year: 2006