Quantitative measurement of airway dimensions on high resolution CT scans and detection of structural lung damage in children who have cystic fibrosis
P. A. de Jong, Y. Nakano, M. H. Lequin, P. D. Pare, H. A. W. M. Tiddens (Rotterdam, The Netherlands; Vancouver, Canada)
Source: Annual Congress 2002 - Bridging the gap - lung function from infancy through childhood
Disease area: Paediatric lung diseases
Abstract High resolution CT (HRCT) scoring systems measure airway wall thickness and a number of other abnormalities in semi-quantitative fashion, technology is available to measure airway wall area (Aaw) quantitatively. Aims: To measure Aaw, total HRCT score (Bhalla), and lung function tests (PFT) in CF-children and to compare changes in Aaw, HRCT score, and PFT. We hypothesized that Aaw is a sensitive marker of disease progression. Methods: 27 CF-children had two scans (CT1 and CT2) in combination with PFT (PFT1 and PFT2). PFT (FEV1, FVC, FEF25-75, Raw, RV and TLC) are expressed as percentage of predicted values (%pred) or as a percentage (FEV1/FVC and RV/TLC). Scans were scored by two observers who matched identical airways on CT1 and CT2. Aaw of matched airways was measured with a validated multi-ray edge detecting method. ΔAaw (Aaw2 –Aaw1), ΔBhalla (Bhalla2 – Bhalla1) and ΔPFT (PFT2 – PFT1) were evaluated using Spearman correlation and unpaired T tests against no change from baseline. Data presented are mean ±] SD. Results: Age at CT1 was 10.1 ±] 4.1 years, time interval between CT1 and CT2 was 1.8 ±] 0.36 years. 418 matched airway pairs were measured. Correlation between ΔAaw and ΔHRCT was not significant (ns) and correlation between ΔAaw and ΔPFT was weak (FEF25-75: R = -0.65, p = 0.01; FEV1/FVC: R = -0.44, p = 0.06).ΔAaw increased with + 0.06 mm (ns); ΔBhalla + 1.8 points (P = 0.004); ΔFEV1 + 4.0%pred (ns). Conclusions: HRCT score increased significantly but airway wall dimensions and PFT did not change significantly in this CF population over a two year period. Aaw does not seem to be a more sensitive marker of progressive lung disease relative to a semi quantitative HRCT scoring system or PFT.
Rating:
You must login to grade this presentation.
Share or cite this content
Citations should be made in the following way:
P. A. de Jong, Y. Nakano, M. H. Lequin, P. D. Pare, H. A. W. M. Tiddens (Rotterdam, The Netherlands; Vancouver, Canada). Quantitative measurement of airway dimensions on high resolution CT scans and detection of structural lung damage in children who have cystic fibrosis. Eur Respir J 2002; 20: Suppl. 38, 257
You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.
Member's Comments
Related content which might interest you:
Related content which might interest you:
Progression of structural lung damage on high resolution CT in cystic fibrosis children with stable lung function Source: Eur Respir J 2002; 20: Suppl. 38, 209s Year: 2002
Progressive damage on high resolution computed tomography despite stable lung function in cystic fibrosis Source: Eur Respir J 2004; 23: 93-97 Year: 2004
Assessment of a new magnetic resonance imaging (MRI)-scoring- system for pulmonary changes in patients with cystic fibrosis (CF) – comparison with clinical parameters and high resolution computed tomography (HRCT) Source: Annual Congress 2006 - New modalities and application in imaging of the chest Year: 2006
Differential diagnosis between pulmonary fibrosis and lung emphysema by analysis of pixel density distribution of high resolution computed tomography (HRCT) Source: Eur Respir J 2004; 24: Suppl. 48, 68s Year: 2004
Quantitative assessment of airway remodeling in severe asthma using high resolution computed tomography Source: Annual Congress 2007 - Imaging modalities in asthma, COPD and emphysema Year: 2007
Correlation between pulmonary function tests and airway diameters, inspiratory-expiratory lung densities with CT and high resolution CT in patients with COPD Source: Annual Congress 2007 - Imaging modalities in asthma, COPD and emphysema Year: 2007
Changes in quantitative measures of airways on computed tomography (CT) in children with cystic fibrosis (CF) Source: Eur Respir J 2005; 26: Suppl. 49, 728s Year: 2005
Correlation of the Brody high resolution computed tomography scoring system with aerobic fitness and lung function in patients with cystic fibrosis Source: Virtual Congress 2021 – Cystic fibrosis in children: various aspects Year: 2021
Correlation between the high resolution computed tomography scoring and lung functions in patients of stable bronchiectasis Source: Annual Congress 2010 - Bronchiectasis and respiratory infections caused by Pseudomonas Year: 2010
Comparison of high resolution computerized tomography (HRCT) of the chest and pulmonary function testing in evaluating the effect of tobramycin solution for inhalation in cystic fibrosis (CF) patients Source: Eur Respir J 2004; 24: Suppl. 48, 387s Year: 2004
Longitudinal changes on high-resolution CT in adults with cystic fibrosis: comparison with spirometry Source: Eur Respir J 2005; 26: Suppl. 49, 729s Year: 2005
Quantitative assessment of chronic lung disease of infancy using computed tomography Source: Eur Respir J 2012; 39: 992-999 Year: 2012
Heterogeneity of narrowing in normal and asthmatic airways measured by HRCT Source: Eur Respir J 2004; 24: 211-218 Year: 2004
Quantitative high-resolution computed tomography fibrosis score: performance characteristics in idiopathic pulmonary fibrosis Source: Eur Respir J, 52 (3) 1801384; 10.1183/13993003.01384-2018 Year: 2018
Prognostic value of a high resolution computed tomography (HRCT) in cystic fibrosis children Source: Eur Respir J 2005; 26: Suppl. 49, 622s Year: 2005
3D PREFUL: Novel high resolution dynamic lung ventilation imaging in patients with asthma, cystic fibrosis and COPD and healthy volunteers Source: Virtual Congress 2020 – Imaging-based phenotyping in pulmonary disease Year: 2020
Longitudinal structural changes using MDCT in patients with combined pulmonary fibrosis with emphysema Source: Virtual Congress 2021 – Imaging Year: 2021
Computed tomography scoring in adults with cystic fibrosis (CF): correlation with clinical and functional measurements Source: Annual Congress 2008 - Cystic fibrosis: factors affecting lung health Year: 2008
The correlation between pathological findings of transbronchial lung cryobiopsy and high resolution CT morphology for diffuse parenchymal lung disease patients Source: International Congress 2018 – What is new in idiopathic interstitial pneumonias? Year: 2018