Source: Annual Congress 2002 - Bridging the gap - lung function from infancy through childhood
Disease area: Paediatric lung diseases

Abstract

We investigated peripheral ventilation distribution in healthy newborn and postconceptional age matched preterm infants with chronic lung disease (CLD) using a sulfur-hexafluoride multiple breath gas washout (MBW). Indices of ventilation inhomogeneity in proximal (Sprox) and peripheral (Sper) lung zones using alveolar phase III slope analysis were calculated. The MBW was performed in 10 infants with CLD at a post-conceptional age of 45-46 weeks and in 10 healthy, age matched controls. An ultrasonic flow meter was used to measure the flow and gas concentration. The measured functional residual capacity per kilogram body weight of CLD infants were similar to volumes measured in healthy infants (16.0 ±] 0.5 and 17.2 ±] 0.5 mL . kg-1, respectively, mean ±] SD, P >0.1). Sprox was not different (1.40±]0.38 mL-1 and 1.90±]0.53 mL-1: healthy vs CLD, respectively, P > 0.1) but Sper was significantly higher in infants with CLD (19.4±]1.2 mL-1 and 25.9±]1.5 mL-1: healthy vs CLD, respectively, P = 0.001). The present study indicates that MBW derived indexes of ventilation distribution can be determined in small infants and changes on the peripheral lung level due to CLD may be detected with this technique.

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Citations should be made in the following way:
A. Schibler, G. L. Hall, M. Zanolari, J. H. Wildhaber, U. Frey (Bern, Zurich, Switzerland). Peripheral ventilation distribution in healthy and prematurely born infants with chronic lung disease. Eur Respir J 2002; 20: Suppl. 38, 255

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