Source: Annual Congress 2002 - Bridging the gap - lung function from infancy through childhood
Disease area: Paediatric lung diseases, Respiratory critical care

Abstract

Introduction: Little is known about the development of forced expiratory flow, a measure of airway patency, in infants with chronic lung disease (CLD). We aimed to evaluate forced expiratory flow, in very low birth weight (VLBW) infants with CLD, treated with high-frequency oscillatory ventilation (HFO) or conventional mechanical ventilation (CMV). Ventilation strategy was determined by availability of HFO or CMV equipment.
Results: In 36 infants with CLD, lung function was evaluated at 6 and/or at 12 months corrected age. Forced expiratory flow (V'_maxFRC) was expressed in Z score (Sly ERJ 2000). Mean (SD) birth weight and gestational age were 837 (152) grams and 26.8 (1.7) weeks, respectively. At 6 and 12 months mean (SEM) V'_maxFRC was -1.7 (0.1) and -2.2 (0.1) respectively: a mean (95% CI) reduction of 0.5 (0.2 to 0.7)(p<0.001). At 12 months mean (SEM) V'_maxFRC in Z score was better in the group who received initial HFO ventilation (n=15) as compared to the group who received CMV (n=16): -1.9 (0.2) and -2.5 (0.1), respectively (mean (95% CI) difference: 0.6 (0.2 to 1.0), p=0.008). Both groups had similar perinatal and patient characteristics.
Conclusion: During the first year of life these VLBW infants with CLD have decreased forced expiratory flows that worsen. Initial treatment with HFO was associated with a more favourable outcome of forced expiratory flows at 12 months corrected age. Supported by GlaxoSmithKline, the Netherlands

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Citations should be made in the following way:
W. Hofhuis, W. A. Huysman, E. C. van der Wiel, J. C. de Jongste, P. J. F. M. Merkus (Rotterdam, The Netherlands). Forced expiratory flows during the first year of life in infants with chronic lung disease: a more favourable outcome after HFO ventilation. Eur Respir J 2002; 20: Suppl. 38, 254

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