Comparable measurements of FRC in healthy infants using three techniques
J. J. Pillow, H. Ljungberg, G. Hulskamp, A. Cantarella, P. Gustafsson, A. Schibler, J. Stocks (London, United Kingdom; Gothenburg, Sweden; Bern, Switzerland)
Source: Annual Congress 2002 - Bridging the gap - lung function from infancy through childhood
Disease area: Paediatric lung diseases
Abstract Plethysmography is the traditional gold standard method of measuring functional residual capacity (FRC). Recent investigations using a new generation plethysmograph (Jaeger) suggest that earlier studies overestimated FRC. Aim: To obtain comparative measurements of FRC using three different techniques. Methods: FRC was measured in 8 unsedated and 7 sedated healthy infants with a mass spectrometer (FRCMS , Innovision) and compared to gas washout using the ultrasonic flow meter (FRCUS , EcoMedics; n=14) or plethysmography (FRCP ; n=7). 4% SF6 was used as the tracer gas for both washout tests. The order of MS and US testing was informally randomised. Plethysmography followed gas washout as sleep state permitted. Results: There was close agreement between FRCMS and FRCUS and between FRCMS and FRCP (see Fig.). The table shows no difference for FRC/kg (p=0.86) or within-subject variability (CV%, p=0.11) in 6 infants measured with all 3 techniques.
MS USFM Pleth FRC ±]SD (mL/kg) 22.6±]4.9 21.3±]5.1 21.4±]3.4 CV±]SD (%) 2.7±]1.0 4.6±]3.0 3.5±]1.7
Conclusions: FRC/kg may be lower than published normative data from body plethysmography suggests. In the healthy infant, gas washout techniques appear to provide comparable values of FRC to body plethysmography.
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J. J. Pillow, H. Ljungberg, G. Hulskamp, A. Cantarella, P. Gustafsson, A. Schibler, J. Stocks (London, United Kingdom; Gothenburg, Sweden; Bern, Switzerland). Comparable measurements of FRC in healthy infants using three techniques. Eur Respir J 2002; 20: Suppl. 38, 253
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