Source: Annual Congress 2002 - Bronchiolitis
Disease area: Airway diseases, Paediatric lung diseases

Abstract

Chronic bronchiolitis (CB) is characterized by irreversible airway obstruction and chronic airway inflammation with neutrophils involvement and release of different inflammatory mediators including interleukin-8 (IL-8). The aim of the study was to investigate bronchoalveolar lavage (BAL) cell profile and levels of IL-8 in blood serum and BALF in children with CB depending of severity of disease and on the degree of bronchial obstruction. We examined 57 children with CB (mean age 11,5±]0,4 years) in periods of marked clinical exacerbation (E) and relative clinical remission (R). Sera from 12 healthy children age 10-12 years were used as controls. Ten adult healthy controls were included for BAL procedure. Concentrations of IL-8 were measured by ELISA. CB was characterized by a high median ratio of neutrophils (from 31,7 to 70,4 %), eosinophils (from 2,1 to 7,9%) and lymphocytes (from 7,6 to 16,5%) in both E and R in all patients compared with healthy controls. We revealed high concentration of IL-8 in BALF (from 880,6 to 1838,3 pg/ml) and serum (from 42,0 to 88,6 pg/ml) in both E and R in all patients compared with healthy controls. Furthermore, BALF concentrations of IL-8 were 10 to 40 times higher as compared to its serum levels. High percentage of neutrophils and levels of IL-8 were revealed especially in patients with severe CB. Data from all CB patients demonstrated correlations between neutrophils (%) and FEV1 (r=-0,845, p<001), between neutrophils (%) and IL-8 (r=0,748; p<0,001). We conclude that neutrophils are dominant type of cells in low airway in children with chronic bronchiolitis.

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Citations should be made in the following way:
G. L. Muryghina, E. V. Boitsova, B. G. Lisotchkin, T. P. Ses, A. V. Bogdanova (St-Petersburg, Russia). Role of neutrophils in airway inflammation in children with chronic bronchiolitis. Eur Respir J 2002; 20: Suppl. 38, 242

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