Source: Annual Congress 2002 - Bronchiolitis
Disease area: Respiratory infections

Abstract

RS-virus infection is one of problems of chronic bronchiolitis. We performed the analysis of RS viral antigen (RSVA) depending on stages et duration of the disease,
number of repeated analyses and presence of viral associations. We examined 45 patients (aged from 2 to 12 years) presenting signs of RS infection confirmed by revealing of RSVA by the method of immunofluorescence with poly- and monoclonal antibodies (AB), as well as by demonstration of specific ABVI the ELISA test and conventional serologic reactions.
Material utilized: epithelial cells obtained by nasal and bronchial brush biopsy, bronchial aspiration fluid and paired blood sera.
Results: RSVA from patients with CB had signs of persistence – presence of AB during exacerbation period (100%), continuous presence of RSVA in nasal and bronchial epithelial cells (77% and 81% respectively), in alveolar macrophages of bronchial aspirates (60%); activation of intensity and extent of luminescence in case of associated acute viral infection (influenza 35%); decreased level of fusion F-protein (by 1.5-2 times) observed following 3-4 repeated exacerbations due to RS infection.
Thus, the problem of chronic bronchiolitis is the problem of viral persistence.

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Citations should be made in the following way:
N. Yakovleva, E. Boitzova, A. Bogdanova (St-Petersburg, Russia). RS virus antigenaemia in children with chronic bronchiolitis. Eur Respir J 2002; 20: Suppl. 38, 241

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