Source: Annual Congress 2002 - Lung cancer biology
Disease area: Thoracic oncology

Abstract

The aim of this work was to study morphological peculiarities and expression of biomolecular tumor markers including IGF family members in lung carcinoma patients lived for long time at Semipalatinsk territories with radioactive contamination.
The investigation drew operated and biopsy materials of 27 lung cancer patients; among them 17 patients (the 1-st group) lived from their childhood to 1993 near the proving ground and experienced radiation for long time (the annual irradiation dose exceeded 0.1 ber). The comparative group involved 10 patients (the 2-nd group) lived at Kazakhstan territories with normal radiation level. There were 23 males and 4 females aged from 45 to 69 years among the patients.We used paraffin embedded archive blocks from Semipalatinsk oncology center.
To detect the tumor histogenesis we used electronic microscopy of paraffin blocks and semi-thin sections stained by methylene blue, azur II, fuxine.
We performed immunohistochemical examination using immune peroxidase method, mono- and polyclonal antibodies against chromogranin, IGFI, IGFII, IGFBP1-6.
The characteristic features of lung carcinomas in residents at the radioactive contaminated territories of Semipalatinsk region (Kazakhstan) were constant presence of dust particles in tumors of various histological types and from different sites.
Lung carcinomas at the Semipalatinsk region have histogenetic peculiarities and they can be characterized as neuroendocrine tumors, not only small cell type but also non-small cell type with neuroendocrine differentiation.
The investigation lung carcinomas have specific mechanisms for tumor growth regulation referred to IGF family with high activity of IGF II and IGFBP1, 2 compared to the 2-nd group.

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Citations should be made in the following way:
G. E. Sagindikova, E. A. Kogan (Moscow, Russia). Lung carcinoma in persons who lived for a long time in radioactive contaminated territories of Semipalatinsk region (Kazakhstan). Eur Respir J 2002; 20: Suppl. 38, 224

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