Source: Annual Congress 2002 - Lung cancer biology
Disease area: Thoracic oncology

Abstract

PURPOSE: Vascular endothelial growth factor (VEGF), produced by many human tumors, is known to play an important role in the formation of tumor neovasculature and to be associated with patients' poor prognosis. On the other hand, several investigators reported that VEGF inhibits dendritic cells (DCs) maturation in vitro and decreases numbers of DCs in vivo. In the present study, we analyzed the relationship between the expression of VEGF and the infiltration of DCs, and their influence on the prognosis of patients with non-small cell lung cancer (NSCLC).
METHODS: Immunohistochemical expression of VEGF in tumor cells, microvessel densities (MVD) in tumor stroma and intra tumoral infiltration of DCs were investigated in 132 patients with surgically resected NCSLC, and their influence on patients[scquote] survival was evaluated.
RESULTS: VEGF expression was positively related to MVD (P = 0.003), and negatively related to the degree of DCs infiltration (P = 0.0232). The prognosis of patients with high VEGF expression or high MVD were significantly worse than that of patients with low VEGF expression (P<0.0001) or low MVD (P<0.0001). The prognosis of patients with high DCs infiltration was significantly better than that of patients with low DCs infiltration (P = 0.0004). Multivariate analysis also showed that these factors are independently related to patients[scquote] prognosis.
CONCLUSION: The present data indicates that the inhibition of DCs by VEGF is seen in clinical specimen with NSCLC, which is consistent with previous in vitro and in vivo experimented data, and that these parameters are prognostic factors of patients with NSCLC.

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N. Inoshima, T. Minami, Y. Nakanishi, M. Izumi, H. Wataya, R. Ishibashi, Y. Horiuchi, N. Hara (Fukuoka, Japan). Inverse correlation between the expression of vascular endothelial growth factor and infiltration of dendritic cells and their influence on the prognosis of nonsmall cell lung cancer. Eur Respir J 2002; 20: Suppl. 38, 220

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