Source: Annual Congress 2002 - New aspects of asthma epidemiology
Disease area: Airway diseases

Abstract

Body mass index (BMI) has been related to asthma in adults; however the mechanisms are not well understood. We investigated the relation between BMI, change in body silhouette, and the risk of asthma in a cohort of French women participating in the E3N study. Over 3 years follow up, we identified 282 incident cases of asthma among 54286 women aged 40 to 65 years at baseline. Women provided information on socio demographic and reproductive factors as well as weight and height, and body figure at different ages (8 silhouettes). Data were analyzed using proportional hazard models to determine the risk of asthma incidence in relation to BMI and body figures adjusted for age, menopausal status, smoking status, total caloric intake and physical activity. Reported BMI (age-adjusted) at baseline was related to the incidence of asthma with a significant increasing trend with increasing BMI (Q1-2 RR= 1.16 95% CI 0.76-1.78; Q1-3 RR= 1.25 95% CI 0.82-1.89; Q1-4 RR= 1.59 95% CI 1.07-2.36; Q1-5 RR= 1.91 95% CI 1.30-2.79, test for trend p<0.0001). Increases in body figure between puberty, 20 years of age and the start of the follow up were significantly related to the risk of asthma with the larger risk observed for an increase of 2 or more silhouettes between puberty and the start of the FU (RR= 1.58 95% 1.13-2.23, adjusted for age) and between 20 years of age and the start of the FU (RR= 1.83 95% CI 1.28-2.59 age-adjusted). We conclude that a high BMI is significantly related to the risk of asthma incidence and that increases in body figures between puberty and adulthood are related to the incidence of asthma later in life.

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Citations should be made in the following way:
I. Romieu, V. Avenel, B. Leynaert, F. Kauffmann, F. Clavel (Cuernavaca, Mexico; Villejuif, France). Body mass index, change in body silhouette and the risk of asthma in the E3N cohort study. Eur Respir J 2002; 20: Suppl. 38, 164

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