Source: Annual Congress 2002 - Pathophysiology of pulmonary hypertension
Disease area: Pulmonary vascular diseases

Abstract

The severity of pulmonary hypertension (PH) is characterized by a decrease in cardiac index (CI) and mixed venous oxygen saturation (SvO2) and an increase in right atrial pressure (Pra). Matrix metalloproteinases (MMP) are involved in arterial remodeling, which is known to be a major component of PH. We hypothesized, therefore, that circulating monocyte proMMP-9 content could be used as a marker of the severity of PH.
Eighteen patients (10 M/8 F, 54±]4 years old) with PH of varying severity (mean pulmonary arterial pressure, Ppa = 43±]4 mmHg, CI = 2.3±]0.1 l.min-1.m-2, Pra = 7±]1 mmHg, SvO2 = 63±]2 %) were studied at the time of diagnosis. PH was related to COPD (n = 4), chronic pulmonary thromboembolism (n = 4) and to primary PH (n = 10). A blood sample was taken during pulmonary artery catheterization. Monocytes were isolated by panning, cultured and proMMP-9 content (expressed as pg.monocyte-1) determined by zymography on gelatin.
ProMMP-9 content (0.57±]0.08 pg.monocyte-1) was correlated positively with SvO2 (r = 0.70, p<0.001), CI (r = 0.64, p<0.005), and negatively with Pra (r = 0.47, p<0.05). No relationship was found between proMMP-9 content and Ppa nor pulmonary vascular resistance.
In conclusion, circulating monocyte proMMP-9 content decreased with increasing severity of PH, suggesting that monocyte MMP-9 protects against pulmonary artery remodeling

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C. Cantini, P. Kieffer, F. Schrijen, P. Malvestio, J. M. Polu, I. Lartaud-Idjouadiène, J. Atkinson, F. Chabot (Nancy, Vandoeuvre-les-Nancy, France). Decrease in circulating monocyte metalloproteinase-9 content with increasing severity of pulmonary hypertension. Eur Respir J 2002; 20: Suppl. 38, 151

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