Source: Annual Congress 2002 - Thoracic oncology: biology

Abstract

In order to determine whether angiogenesis is a prognostic marker for survival in lung cancer, we performed a systematic review of the literature. Published studies on lung cancer assessing MVC were identified by an electronic search in order to aggregate the survival results, after a methodological assessment using a scale designed by the European Lung Cancer Party. MVC was assessed by factor VIII in 14 studies, by CD34 in 10 and by CD31 in 8. They included respectively 1866, 1440 and 1093 patients. All of them considered non-small cell lung cancer (NSCLC).The overall median quality scores were respectively 52, 59 and 59% without a significant difference between studies assessable or not for meta-analysis nor between studies with significant and non significant results. Seven studies about factor VIII, 9 about CD34 and 7 about CD31 provided sufficient data to allow a meta-analysis of the survival results. The meta-analysis showed that a high MVC was a statistically significant poor prognostic factor for survival in NSCLC when assessed by factor VIII (HR: 1.71 ; 95% CI: 1.44-2.03), CD34 (HR 1.95: ; 95% CI: 1.65-2.30) or CD31(HR: 1.40; 95% CI:1.17-1.68).

Rating:

Share or cite this content

Citations should be made in the following way:
A. P. Meert, B. Martin, M. Paesmans, J. M. Verdebout, T. Berghmans, J. J. Lafitte, P. Delmotte, C. Mascaux, J. P. Sculier (Brussels, Belgium; Lille, France). The role of angiogenesis, assessed by microvessel count (MVC), on the survival of patients with lung cancer: a systematic review of the literature with meta-analysis. Eur Respir J 2002; 20: Suppl. 38, 140

Member's Comments

No comment yet.

Related content which might interest you: The role of EGFR expression in the survival of patients with lung cancer: a systematic review of the literature with meta-analysis Source: Eur Respir J 2001; 18: Suppl. 33, 478s Year: 2001 Role of p53 as a prognostic factor for survival in lung cancer: a systematic review of the literature with a meta-analysis Source: Eur Respir J 2001; 18: 705-719 Year: 2001 The role of EGF-R expression on patient survival in lung cancer: a systematic review with meta-analysis Source: Eur Respir J 2002; 20: 975-981 Year: 2002 Role of ras protoncogene in survival of patients with lung cancer: a systematic literature review and meta-analysis Source: Eur Respir J 2004; 24: Suppl. 48, 478s Year: 2004 COX-2 as prognostic factor in lung cancer: systematic review of the literature with meta-analysis Source: Annual Congress 2005 - Prognostic factors in lung cancer Year: 2005 Surrogate markers predicting overall survival for lung cancer: ELCWP recommendations Source: Eur Respir J 2011; 39: 9-28 Year: 2012 Surrogate markers predicting overall survival for lung cancer: ELCWP recommendations Source: Eur Respir J 2012; 39: 9-28 Year: 2012 Late-breaking abstract: Is primary tumour standardized uptake value (SUV) an independent prognostic factor for non small cell lung cancer (NSCLC)? A meta-analysis based on individual data Source: Annual Congress 2011 - Imaging, functional evaluation and staging for lung cancer patients Year: 2011 Effects of exercise training in people with non-small cell lung cancer before lung resection: a systematic review and meta-analysis. Source: Virtual Congress 2021 – Innovation in thoracic surgery Year: 2021 Relevance of clinical TNM-staging in small cell lung cancer (SCLC) for survival – A retrospective case study in 633 patients Source: Annual Congress 2010 - Staging of lung cancer Year: 2010 Validation and comparison of several published prognostic systems for patients with small cell lung cancer Source: Eur Respir J 2011; 38: 657-663 Year: 2011 Prognostic value of mean platelet volume in non-small cell lung cancer: a real-world, registry-based study Source: International Congress 2019 – Early detection, follow-up and epidemiology of lung cancer Year: 2019 A meta-analysis assessing the prognostic value of neutrophil to lymphocyte ratio in lung metastasectomy for colorectal cancer Source: Virtual Congress 2021 – Innovation in thoracic surgery Year: 2021 Prophylactic cranial irradiation in small cell lung cancer: a systematic review of the literature with meta-analysis Source: Eur Respir J 2001; 18: Suppl. 33, 319s Year: 2001 Systematic review of the effect of chemotherapy on quality of life (QoL) and symptom control in patients with non-small cell lung cancer (NSCLC) Source: Annual Congress 2006 - Lung cancer treatment Year: 2006 Systematic evaluation of the efficacy-effectiveness gap of systemic treatments in extensive disease small cell lung cancer (ED SCLC) Source: International Congress 2019 – Treatment of lung cancer Year: 2019 Tumour growth rate as a tool for response evaluation during PD-1 treatment for non-small cell lung cancer: a retrospective analysis Source: ERJ Open Res, 5 (4) 00179-2019; 10.1183/23120541.00179-2019 Year: 2019 The prognosis of the neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in lung cancer and the association with treatment: a retrospective study> Source: International Congress 2017 – Lung cancer - clinical research: scientific pearls from the bedside Year: 2017 Limited role of Ki-67 in lung carcinoid tumor patients predicting overall short-term survival,A single institution experience Source: International Congress 2018 – Lung cancer: novel prognostic markers and scores Year: 2018 A retrospective study of the cause and impact of delayed diagnosis of lung cancer (LC) Source: Annual Congress 2008 - Management, quality aspects and prognosis in thoracic oncology Year: 2008