Source: Annual Congress 2002 - Thoracic oncology: biology
Disease area: Thoracic oncology

Abstract

Natural killer (NK) cells have been implied in the resistance against certain tumors and virally-infected cells. The prognostic significance of tumor infiltrating NK cells in primary non-small cell lung cancer (NSCLC) has not been fully studied. Seventy patients with primary NSCLC were evaluated for the presence of tumour infiltrating natural killer cells subset CD57 (TINK) after surgery. None of them received adjuvant therapy. Immunohistochemical studies of surgery pieces were performed by using the monoclonal antibody CD57 (Villegas, FR et al. Lung Cancer 2002; 35:23-28.). The reference value used was the median (5 TINK cells/field) of all tumors analyzed. Of 70 patients finally evaluated 67 were men. Mean age was of 66.84 ±] 8.29 years old. After a minimun follow-up of 2 years the Kaplan-Meier method was used to obtain survival curves. Multivariate analysis were performed by using the Cox regression model. The survival was significantly better in patients with more than 5 TINK cells/field (Logrank p= 0.040). This correlation is significantly higher in those patients with squamous cell carcinoma at stages IB (Logrank p= 0.001). In the multivariate analysis including TNM (surgical-pathologic stage), age, and endoscopy localization, the risk of death in patients with less than 5 TINK cells/field was 2.32 fold higher (CI 95%; range 1.09-5.01) than in those patients with more than 5 TINK cells/field. In conclusion, these results show that TINK cells appear to be a prognostic factor in the survival of patients with NSCLC.

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F. R. Villegas, M. Zuil, J. Jareño, M. J. Chillón, E. Arias, F. Roig, S. Coca, L. Callol (Madrid, Spain). Prognostic significance of tumour-infiltrating natural killer cells subset CD57 in patients with nonsmall cell lung cancer. Eur Respir J 2002; 20: Suppl. 38, 139

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