Source: Annual Congress 2003 - Assessing airway function: practicalities and clinical applications
Disease area: Airway diseases

Abstract

Introduction: In our pulmonary function laboratory we are able to measure airway resistance with bodyplethysmography, impulsoscillometry and the interruptor technique. In this study we compared these methods and we estimated predicted values.
Method: In 73 healthy adults (aged 18-78 years) we compared R_eff, R_tot, R_0,5, R_20Hz, R_5Hz and R_int. We performed the measurements in one session and in a random order.
Results: The various R values were significantly different, p-values variated from 0.000 to 0.027. R_tot, R_eff and R_0,5 correlated well (correlation between 0.72 and 0.97). R_tot correlated well with R_20Hz, R_5Hz and R_int (correlation 0.63 and 0.82), but the correlation between R_eff and R_0,5 with R_20Hz, R_5Hz and R_int respectively was moderate (correlation between 0.48 and 0.55). The variability of all variables appeared to be comparable. The resistances were not significanly dependent on age and height. Therefore, we estimated means and standard deviations for all the variables mentioned above. We found R_eff = 0.15 ± 0.06 (SD) kPa.l^-1.s, R_tot = 0.19 ± 0.07 (SD) kPa.l^-1.s, R_0,5 = 0.13 ± 0.05 (SD) kPa.l^-1.s, R_20Hz = 0.26 ± 0.09 (SD) kPa.l^-1.s, R_5Hz = 0.30 ± 0.10 (SD) kPa.l^-1.s and R_int = 0.24 ± 0.08 (SD) kPa.l^-1.s.
Conclusions: Because of the moderate correlation we concluded that the various parameters don‘t describe the same mechanism. In further research we will study which parameter is separating best healthy from disease.

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Citations should be made in the following way:
K. van der Velden-van Etten, K. Nietzman-Lammering, R. Hoek, P. Zanen, H. Stam (Rotterdam, Utrecht, The Netherlands). Comparison of airway resistance measured with three different techniques. Eur Respir J 2003; 22: Suppl. 45, 3621

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