Source: Annual Congress 2003 - Assessing airway function: practicalities and clinical applications
Disease area: Airway diseases

Abstract

Introduction: Although in COPD patients the reversibility of FEV₁ is not significant, patients often feel better after bronchodilatation. Therefore, bronchodilatator responsiveness of FEV₁ is compared with that of airway resistance.
Method: We performed a reversibility test using 1000 μg Terbutaline. We measured FEV₁ with a Lilly type flow transducer and airway resistance with bodyplethysmografie, impulsoscillometry and the interuptor technique respectively. In 73 healthy adults (aged 18 - 78 years) and in 26 adult COPD patients (aged 42 - 79 years) the reversibility of FEV₁ was compared with that of R_eff, R_tot, R_0.5, R_20Hz, R_5Hz and R_int. We performed the measurements during one session and in a random order.
Results: Reversibility on basis of FEV₁ was not significant in normals as well as in COPD patients. In the healthy volunteers the resistance values were not significant lower after bronchodilatation. However, in the group of COPD patients R_eff, R_tot, R_0,5 and R_int were decreasing significantly. Although the changes in R_20Hz and R_5Hz were not significant, the difference between R_20Hz and R_5Hz before and after bronchodilatation appeared to be significant.
Conclusion: We observed a significant reversibility of COPD patients, when measured airway resistance with bodyplethysmografie and interruptor technique. The difference between R_20Hz and R_5Hz before and after bronchodilatation was sensitive to separate COPD from normals, while R_20Hz and R_5Hz itself were not.

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Citations should be made in the following way:
K. Nietzman-Lammering, K. van der Velden-van Etten, R. Hoek, P. Zanen, H. Stam (Rotterdam, Utrecht, The Netherlands). Comparison of bronchodilatator response of FEV₁ and airway resistance. Eur Respir J 2003; 22: Suppl. 45, 3618

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