Source: Annual Congress 2003 - COPD: a multicomponent disease
Disease area: Airway diseases, Pulmonary vascular diseases

Abstract

Purpose: The aim of this study was to ascertain the influence of COPD on ventricular diastolic dysfunction.
Methods: We studied 19 COPD patients (age 65,8±6,4), 10 in group ΙΙa and 9 in ΙΙb according to GOLD criteria, with echocardiography. Parameters measured included isovolumic relaxation time(IVRT=time from semilunar valve closure to atrioventricular (AV) valve opening), early and late AV flow velocities (E and A wave respectively), E/A ratio in right (RV) and left (LV) ventricle. Pulmonary arterial hypertension (PH) was assessed by measuring the systolic pressure of pulmonary artery.
Results:RV IVRT was found abnormal, i.e 30±10ms, in COPD (56.2±16.1) while LV IVRT was preserved (85,3±16). The E/A ratio was found abnormal and the PH was moderatelly increased. E/A left was statistically significantly correlated with FEV1(%pred)(r=-0,52) and with PH (r= -0,45). There was also a statistically significant difference in E/A left between COPD of IIa and IIb severity according to GOLD.
CONCLUSION : Our results show that COPD has a negative influence on ventricular diastolic function.

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K. M. Antoniou, A. Dermitzakis, M. Ferdoutsis, G. Meletis, G. Patsourakis, N. Bachlitzanakis (Heraklion, Greece). Τhe influence of pulmonary disease on ventricular diastolic dysfunction in COPD patients. Eur Respir J 2003; 22: Suppl. 45, 3375

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