Source: Annual Congress 2003 - COPD: a multicomponent disease
Disease area: Airway diseases

Abstract

The aim of this study was to evaluate the determinants of body mass and the value of tumor necrosis factor-alpha (TNF-a) as a marker of weight-loosing in COPD patients, in association with burden of oxidative stress.
Fifty-two male COPD patients (mean age 62.55±6.81) were included in the study. After anthropometric measurements and standard spirometry, serum TNF-a concentration was measured by ELISA using hTNF-a kit (BioSource, cat No: KHC 3012), and malonyldialdehyde (MDA) by Yoshioka-Kawada method.
Mean body mass index (BMI) was 24.82±3.46 in study population. BMI was lower than normal (<19) in 6 patients. BMI was lower in patients with severe (FEV₁<50%) airflow obstruction (p=0.044). Mean serum TNF-a concentration was 14.99±8.98 pg/ml and MDA was 0.93±0.13 nmol/mL. There was no significant correlation between serum MDA and TNF concentrations (p=0.140). BMI was negatively correlated to burden of smoking (pack-years) (r= -0.392, p= 0.004); but not to pulmonary functions, degree of hypoxemia, serum TNF-a or MDA levels. BMI was significantly lower in current smokers than exsmokers (p=0.041); however, serum MDA and TNF levels were similar in both groups.
The results of this study indicate that body mass is related to severity of airflow obstruction and smoking status (both cigarette burden and continuance to smoking) in COPD; however, serum TNF-a concentration does not seem to be a good marker of weight loosing in these patients.

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Citations should be made in the following way:
F. Karadag, A. B. Karul, O. Cildag, C. Altun, O. Gurgey (Aydin, Turkey). Body mass is related to smoking status and severity of airflow obstruction in COPD. Eur Respir J 2003; 22: Suppl. 45, 3369

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