Source: Annual Congress 2003 - COPD: a multicomponent disease
Disease area: Airway diseases

Abstract

Skeletal muscle can change in response to many stimuli, such as detraining, undernutrition, hypoxemia. There are few studies in patients with chronic respiratory failure and persistent hypoxemia. Purpose:to assess the skeletal muscle fiber type distribution and morphometry, using biopsies of biceps brachii obtained from patients with COPD and chronic hypoxemia, and with normal body mass index(BMI). All the patients signed an informed consent, the project was approved by the Research Etics Committee of our institution. Eight patients - 07 men/01 woman, mean age 54,7 years, mean BMI:25,7, mean FEV1:34,7(%pred), mean PaO₂(room air) 49,66 mmHg - were included in the study; 12 controls (9 men/3 women, mean age 48,3 years), without any respiratory antecedents, were chosen from the biopsies of biceps brachii with normal results. All the specimens were submitted to histochemical staining in order to identify the various fiber types. After that, the area of the muscle fibers was measured (only of the men, in both groups). Results: the frequency of IIA and IID fibers differed between cases and controls, with a reduction of IIA fibers (oxidative) in hypoxemic patients, while the IID fibers (glicolitic) were increased in the patients (p<0.05). The mean area of IID fibers was increased in patients when compared to controls (p<0.05). Both differences, in distribution and mean area suggest that fiber changes might have occured as an adaptation to a predominantly glicolitic metabolism in the patients, as a result of chronic hypoxemia.

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M. C. Pereira, R. N. Isayama, J. C. Seabra, G. Campos, I. A. Paschoal (Campinas, Brazil). Assessment of skeletal muscle fiber type distribution and morphometry in patients with COPD and chronic hypoxemia. Eur Respir J 2003; 22: Suppl. 45, 3368

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