Source: Annual Congress 2003 - COPD: a multicomponent disease
Disease area: Airway diseases

Abstract

OBJECTIVE: To study the prevalence of osteoporosis (OP) and osteopenia in COPD patients and to investigate the relationship between structural severity, body composition and the indices of respiratory function. METHODS: Ten patients with COPD were enrolled prospectively: 8 men (80%) and 2 women (20%), mean age 62.6 ± 9.3; they were studied clinically, radiological, and by dual energy x-ray absorptiometry. Fat mass (FM), lean mass, bone mineral content (BMC) and bone mineral density (BMD) were obtained by dual-energy X-ray densitometry. RESULTS: OP and osteopenia as defined by the World Health Organization (T score < -2.5 SD and between -1 and -2.5 SD, respectively) were observed in 5 patients (50%) and 4 patients (40 %) at the lumbar spine and in 2 (25%) and 6 patients (75%) at the femoral neck, respectively. Patients with OP had a lower body mass index (BMI, 22.9±2.9 kg/m² vs. 26.2±7.6 kg/m²) and fat mass percentage (21.2±4.5% vs. 22.3±15.6%) than patients with osteopenia. Vital capacity (VC, 49.4±9.4% vs. 70.6±10%) and forced expiratory volume (FEV1, 35.8±12.8% vs. 55.7±14.9%) were lower in patients with OP as compared to patients with osteopenia. CONCLUSION: (1) OP is frequent in COPD patients. (2) COPD patients are more susceptible to develop OP when they have low BMI, low fat mass percentage, and active and severe disease.

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Citations should be made in the following way:
V. Zbranca, V. Mocanu, I. Dascalescu, E. Zbranca (Iasi, Romania). Body composition and osteoporosis in COPD patients. Eur Respir J 2003; 22: Suppl. 45, 3366

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