Influence of body weight and fat mass on pulmonary function and performance status of COPD patients
F. De Benedetto, A. Del Ponte, S. Marinari, A. Spacone, M. Castronuovo (Chieti, Italy)
Source: Annual Congress 2003 - COPD: a multicomponent disease
Session: COPD: a multicomponent disease
Session type: Poster Discussion
Number: 3365
Disease area: Airway diseases
Abstract Recent studies show that overweight can influence respiratory functional status of healthy and COPD population. The purpose of our study was to evaluate whether body weight and fat mass (FM) could influence pulmonary gases exchange and performance status of a large stable COPD population (218 pts) (FEV1: X= 43.9 ± 15.1 % pred.; Max: 79%, Min: 14%), including patients with chronic respiratory failure in long term oxygen therapy. All patients were submitted to anthropometric measurements (BMI), respiratory functional tests ( VC, FVC, FEV1, MIP, MEP), blood gas analysis (PaO2, PaCO2), 6 minute walking test (6‘WT) with the evaluation of dyspnea degree (VAS and Borg scale) and bioimpedance analysis (BIA Akern) to evaluate body composition. Results showed a significant direct correlation between BMI and PaCO2, VAS, Borg (respectively p<0.05, p<0.000 and p<0.000) and an indirect correlation between BMI and PaO2, 6‘WT, MIP and MEP (respectively p<0.02, p<0.01, p<0.02 and p<0.007), Similar significant correlation was found with fat mass (FM). In conclusion, body weight and FM increase influence, development of chronic respiratory failure and dyspnea in COPD patients, for both the increasing cardiac load and respiratory muscle fatigue of thoracic wall and diaphragm, due to the higher pressure exerted by intrabdominal adipose accumulation.
Rating:
You must login to grade this presentation.
Share or cite this content
Citations should be made in the following way:
F. De Benedetto, A. Del Ponte, S. Marinari, A. Spacone, M. Castronuovo (Chieti, Italy). Influence of body weight and fat mass on pulmonary function and performance status of COPD patients. Eur Respir J 2003; 22: Suppl. 45, 3365
You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.
Member's Comments
Related content which might interest you:
Related content which might interest you: