Source: Annual Congress 2003 - COPD: a multicomponent disease
Disease area: Airway diseases

Abstract

Objectives : Chronic wasting and body weight loss are commonly observed in patients with COPD, although the mechanistic bases of these changes are still unknown. Leptin and leptin receptor (LEPR) are postulated to play important roles in the control of body composition and energy expenditure. An association study between the human LEPR gene Gln223Arg polymorphism and BMI or fat mass has suggested that A allele have higher BMI and fat mass than G homozygotes. The aim of this study was to explore whether Gln223Arg polymorphism of LEPR could be associated with the presence of COPD in Japanese population.
Methods : The differences in LEPR Gln223Arg allele frequency were examined in 98 patients with smoking-related COPD (59 men and 39 women) and 106 smoker/ex-smoker control subjects matched for sex and age, using the PCR-RFLP technique.
Results : The body mass index (BMI) and body weight were significantly lower in the COPD patients than in the controls (p<0.05). The LEPR Gln223Arg allele frequency was not statistically different between the groups: 0.852/0.148 in COPD patients and 0.788/0.212 in smoker/ex-smoker control subjects. However, A allele frequency tended to be lower in COPD patients compared with that in control subjects (p=0.09).
Conclusion : These results suggest that Gln223Arg polymorphism of LEPR gene was not associated with the development of COPD (odds ratio = 1.55; 95% CI = 0.93 – 2.59).

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K. Tatsumi, T. Hashimoto, S. Sakao, Y. Shino, H. Shirasawa, Y. Kasahara, H. Igari, K. Kurosu, N. Tanabe, Y. Takiguchi, T. Kuriyama (Chiba, Japan). The human leptin receptor gene Gln223Arg polymorphism and the presence of COPD. Eur Respir J 2003; 22: Suppl. 45, 3362

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