Source: Annual Congress 2003 - COPD: a multicomponent disease
Disease area: Airway diseases

Abstract

We studied the effect of a low dose testosterone on body composition, pulmonary function and subjective perceptions such as quality of life and sexuality in 29 patients with moderate to severe COPD. Participants were randomized to receive either 250 mg of testosterone or placebo intra-muscularly every 4 weeks for 26 weeks. Twenty-seven patients completed the study. Fat-free mass increased from baseline in the treatment group at 12 weeks (p<0.05), and a significant difference between the treatment and the control group was seen after 26 weeks (p<0.05). Total body fat mass decreased compared to baseline in the treatment group, at 12 weeks (p<0.01) and at 26 weeks (p<0.05), and there was a significant difference between the treatment and the control group after 12 weeks (p<0.01). The International Index of Erectile Function score increased non-significantly in the treatment group, decreased significantly in the control group (p<0.05) and a significantly better erectile function was reported in the treatment group at the final visit (p<0.05). The overall sexual quality of life improved non-significantly in the treatment group, and was significantly better after 12 weeks compared to the control group (p<0.05). Pulmonary function was unaffected.
In conclusion, administration of a low dose testosterone to men with COPD for 26 weeks was associated with improvement of body composition, better erectile function and sexual quality of life. Furthermore, there were no clinical or biochemical side effects.

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J. Svartberg, U. Aasebo, A. Hjalmarsen, J. Sundsfjord, R. Jorde (Tromso, Norway). Testosterone treatment increases fat-free mass, reduces fat mass and improves sexual function in men with COPD, in a 6-month randomized controlled trial. Eur Respir J 2003; 22: Suppl. 45, 3361

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