Source: Annual Congress 2003 - COPD: a multicomponent disease
Disease area: Airway diseases

Abstract

Cigarette smoke is a major risk factor for the development of COPD. The increased burden of oxidants in cigarette smoke results in activation of redox-sensitive transcription factors which regulate the genes of proinflammatory mediators. Therefore, inflammation is the hallmark of COPD. On the other hand, antioxidative systems protect lung tissue against the oxidative stress injury. We hypothesized that there is a close link between antioxidative enzyme catalase (CAT) and plasma levels of orosomucoid (ORM). ORM is an inflammatory protein with some antioxidant properties. 115 prospective patients with COPD were divided into two groups matched for sex and age depending on their red blood cell levels of CAT: in the first, control group (n= 35) CAT was within the normal range (<4.3 ukat/gHb), in the second group (n=80) CAT was increased (≥4.3 ukat/gHb). Levels of plasma orosomucoid (ORM) were significantly higher in the group with increased CAT compared to controls (1.01±0.04 versus 0.83±0.05 g/l, p<0.05). In addition, there was a significant direct relationship between the activity of CAT and plasma levels of ORM (r=0.234, p<0.02). Our results indicate that induction of oxidative stress as evidenced by increased CAT in red blood cells is associated with paralell increases in plasma levels of inflammatory protein ORM. Further studies are needed to clarify the role of inflammatory proteins in antioxidative defence mechanisms in COPD.
Funded by Medical Faculty UPJS and Ministry of Education, Slovakia

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D. Petrasova, R. Tkacova, A. Trejbalova, J. Stubna, A. Sipulova (Kosice, Slovakia). Circulating inflammatory proteins and red blood cells antioxidant activity in patients with COPD. Eur Respir J 2003; 22: Suppl. 45, 3360

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