T-cell mediated inflammation is is not required for sustained AHR that persists in mice following chronic allergen challenge

R. Leigh, D. Southam, R. Ellis, P. M. O‘Byrne, J. Wattie, R. Sehmi, Y. Wan, M. D. Inman (Hamilton, Canada)

Source: Annual Congress 2003 - Immunology and airway reactivity in animal models of allergic asthma
Session: Immunology and airway reactivity in animal models of allergic asthma
Session type: Thematic Poster Session
Number: 3034
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
R. Leigh, D. Southam, R. Ellis, P. M. O‘Byrne, J. Wattie, R. Sehmi, Y. Wan, M. D. Inman (Hamilton, Canada). T-cell mediated inflammation is is not required for sustained AHR that persists in mice following chronic allergen challenge. Eur Respir J 2003; 22: Suppl. 45, 3034

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
A role for Th1 cells in airway remodeling and hyperreactivity in mice subjected to chronic allergen exposure
Source: Eur Respir J 2007; 30: Suppl. 51, 734s
Year: 2007

In vivo blockade of CTLA-4 counteracts inhalation tolerance and leads to development of allergic airway inflammation in mice repeatedly exposed to aerosolized ovalbumin
Source: Eur Respir J 2004; 24: Suppl. 48, 6s
Year: 2004

Intranasal dust exposure decreases Th2 driven allergic inflammation and increases the Th17 response in mice
Source: Annual Congress 2009 - Animal models of airways inflammation
Year: 2009


VIP knockout mice show asthma-like airway hyper-reactivity, and inflammatory response to immunologic challenge
Source: Eur Respir J 2004; 24: Suppl. 48, 658s
Year: 2004

Modulation of inflammatory cells apoptosis induced by oral tolerance in a model of chronic allergic airway inflammation in guinea pigs
Source: Annual Congress 2005 - Regulation of the allergic and asthmatic response
Year: 2005


Attenuation of airway mucosal dendritic cell function in the induction of T cell hyporesponsiveness following chronic aeroallergen exposure
Source: Annual Congress 2010 - Animal models of asthma and lung inflammation
Year: 2010


Induction of T cell anergy by high dose allergen in allergic mice and underlying mechanism
Source: Annual Congress 2007 - Mouse models of allergic airway inflammation
Year: 2007


Transgenic mice overexpressing IL-18 display increased IL-13 in the airways but no changes of the airway hyperresponsiveness in a murine model of late-phase asthma: evidence for a dual role of IL-18 on mucosal Th1/Th2 responses
Source: Eur Respir J 2002; 20: Suppl. 38, 1s
Year: 2002

Antigen capture and processing by airway dendritic cells is attenuated in mice following chronic aero-allergen exposure
Source: Annual Congress 2009 - Novel mechanisms in the pathogenesis of asthma
Year: 2009

IL4 in patients of bronchial asthma induced by mould sensitization via early and late phase of atopy and delayed T-cell mediated hypersensitivity
Source: Eur Respir J 2006; 28: Suppl. 50, 230s
Year: 2006

Evidence for secretion of IL-18 in asthmatic airway inflammation assessed by endobronchial allergen challenge and its relationship to accumulation of inflammatory cells
Source: Eur Respir J 2001; 18: Suppl. 33, 531s
Year: 2001

Dose-dependent effects of muIL-13Rα2, a potent IL-13 neutraliser, on the phenotype of an acute allergic airways inflammation model in BALB/c mice
Source: Annual Congress 2004 - Animal models of asthma and chronic bronchitis and their relevance in pulmonary pharmacology
Year: 2004


Interferon-γ-pretreated dendritic cells induced dual Th1 and Th2 responses and failed to prevent development of allergic airway inflammation
Source: Eur Respir J 2006; 28: Suppl. 50, 230s
Year: 2006

Increased susceptibility to airway allergic responses in CD40 deficient mice
Source: Eur Respir J 2002; 20: Suppl. 38, 567s
Year: 2002

Effect of previous physical conditioning on pulmonary inflammation and allergic immune response in a chronic allergic airway inflammation in mice
Source: Eur Respir J 2007; 30: Suppl. 51, 370s
Year: 2007

Expression of complement proteins in the lung following allergen sensitization and challenge in mice
Source: Eur Respir J 2006; 28: Suppl. 50, 591s
Year: 2006

IL-17R-deficient mice generate a Th2 response and altered leukocyte trafficking in a model of pulmonary inflammation
Source: Eur Respir J 2003; 22: Suppl. 45, 194s
Year: 2003

IL-33 blockade prevents exacerbations in a model of chronic airway inflammation by blunting persistent inflammation and remodeling
Source: International Congress 2019 – Advances in asthma pharmacology
Year: 2019

HDM-challenged mice exhibit impaired interferon response to TLR3 ligand in a murine model of viral asthma exacerbation
Source: International Congress 2015 – Animal studies of asthma and other inflammatory conditions
Year: 2015

Susceptibility to asthma exacerbation induced by superantigen is critically dependent on bystander mucosal Vβ8 TCR T cells in TH2 immune mice
Source: Eur Respir J 2001; 18: Suppl. 33, 19s
Year: 2001