Cigarette smoke augments MUC5AC mucin production via TLR3-EGFR pathway in airway epithelial cells

K. Kanai, A. Koarai, H. Sugiura, T. Ichikawa, T. Kikuchi, K. Akamatsu, T. Hirano, M. Nakanishi, K. Matsunaga, Y. Minakata, M. Ichinose (Wakayama, Sendai, Japan)

Source: Annual Congress 2013 –Stress responses and T-cell behaviour in the lung
Session: Stress responses and T-cell behaviour in the lung
Session type: Thematic Poster Session
Number: 3889
Disease area: Airway diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
K. Kanai, A. Koarai, H. Sugiura, T. Ichikawa, T. Kikuchi, K. Akamatsu, T. Hirano, M. Nakanishi, K. Matsunaga, Y. Minakata, M. Ichinose (Wakayama, Sendai, Japan). Cigarette smoke augments MUC5AC mucin production via TLR3-EGFR pathway in airway epithelial cells. Eur Respir J 2013; 42: Suppl. 57, 3889

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Role of chronic exposure to cigarette smoke on endoglin/CD105 expression in airway epithelium
Source: International Congress 2015 – Cellular and molecular mechanisms of COPD and emphysema
Year: 2015

Recurrent cigarette smoke exposure impairs SIRT1 shuttling in bronchial epithelial cells
Source: International Congress 2016 – Translational studies in lung disease
Year: 2016

Cigarette smoke induced Muc5AC is regulated by CARM1 in an ex-vivo airway model
Source: Annual Congress 2013 –Molecular biology: state-of-the-art 2013
Year: 2013



Cigarette smoke impairs Sirt1 activity and promotes pro-inflammatory responses in bronchial epithelial cells
Source: International Congress 2015 – Immunomodulation: basic science and clinical aspects
Year: 2015

Cigarette smoke impairs autophagic flux in bronchial epithelial cells
Source: Annual Congress 2013 –Stress responses and T-cell behaviour in the lung
Year: 2013

The AMPK-TSC1/2-mTOR signaling pathway regulates cigarette smoking-induced inflammation and apoptosis in airway epithelial cells
Source: International Congress 2015 – Molecular pathways of lung injury due to tobacco-related products
Year: 2015


Quercetin attenuates inflammation in cigarette smoke stimulated airway epithelial cells: Possible involvement of autophagy
Source: Annual Congress 2013 –New drugs in respiratory medicine
Year: 2013


Cigarette smoke modulates the PKAc-associated cross-coupling between NF-kB and glucocorticoid receptor in primary small airway epithelial cells
Source: Annual Congress 2013 –The pulmonary epithelium: recent developments
Year: 2013

IL-8 and TSLP production as markers of bronchial epithelial cell activation in IL-17A mediated airway inflammation in COPD: Role of tiotropium
Source: Annual Congress 2013 –New insights into epigenetic mechanisms in the lung
Year: 2013

Effect of whole cigarette smoke exposure and CCSP on MUC5AC mucin production in primary cultures of human bronchial epithelial cells at air-liquid interface of COPD, smokers and control patients
Source: International Congress 2015 – Translational studies in airway cell biology
Year: 2015

Cigarette smoke modulates rhinovirus-induced airway epithelial cell chemokine production
Source: Eur Respir J 2010; 35: 1256-1263
Year: 2010



Cigarette smoke induces a distinct fibrotic signature in bronchial epithelial cells
Source: Annual Congress 2012 - The smoking gun in COPD biology
Year: 2012

Cigarette smoke reduces pro-resolving omega-6 metabolite production by cultured human primary bronchial epithelial cells
Source: International Congress 2015 – Cellular and molecular mechanisms of COPD and emphysema
Year: 2015

Cigarette smoke extract induces the release of extracellular vesicles by airway epithelial cells via cellular carbonyl stress
Source: International Congress 2015 – Immunomodulation: basic science and clinical aspects
Year: 2015

Cigarette smoke upregulating the expression of miR 21 increases IL-8 in airway epithelial cells
Source: International Congress 2018 – New kids on the block: novel molecular pathways and therapeutic targets in chronic lung diseases
Year: 2018



Cigarette smoke induce Epithelial-Derived Inflammation through activating autophagy via RAGE signaling in bronchial epithelial cells.
Source: International Congress 2019 – Effects of environmental exposures in lung pathology and the underlying mechanisms
Year: 2019

Cigarette smoke impairs airway epithelial barrier function and cell–cell contact recovery
Source: Eur Respir J 2012; 39: 419-428
Year: 2012



Cigarette smoke induces mitochondrial dysfunction via PKCd-p66Shc signaling pathway in human bronchial epithelial cells
Source: International Congress 2018 – COPD: novel pathological mechanisms in the airway epithelium
Year: 2018

PINK1-Parkin pathway-mediated mitophagy is involved in cigarette smoke extract (CSE)-induced cellular senescence in human bronchial epithelial cells (HBEC)
Source: International Congress 2014 – Effect of cigarette smoke on cell behaviour: cell biology, signalling and senescence
Year: 2014