SIRT6-induced activation of autophagy inhibits CSE-induced bronchial epithelial cell senescence

N. Takasaka, J. Araya, H. Hara, S. Ito, S. Fujii, K. Shimizu, M. Kawaishi, T. Numata, T. Morikawa, K. Nakayama, K. Kuwano (Tokyo, Japan)

Source: Annual Congress 2013 –New insights into epigenetic mechanisms in the lung
Session: New insights into epigenetic mechanisms in the lung
Session type: Oral Presentation
Number: 3516
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
N. Takasaka, J. Araya, H. Hara, S. Ito, S. Fujii, K. Shimizu, M. Kawaishi, T. Numata, T. Morikawa, K. Nakayama, K. Kuwano (Tokyo, Japan). SIRT6-induced activation of autophagy inhibits CSE-induced bronchial epithelial cell senescence. Eur Respir J 2013; 42: Suppl. 57, 3516

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
SIRT6-induced activation of autophagy inhibits CSE-induced bronchial epithelial cell senescence
Source: Annual Congress 2011 - Epithelial cells: role in health and disease
Year: 2011

Parkin-mediated mitophagy is involved in cigarette smoke extract (CSE)-induced cellular senescence in human bronchial epithelial cells (HBEC)
Source: Annual Congress 2013 –Stress responses and T-cell behaviour in the lung
Year: 2013

Involvement of mitochondrial fragmentation in cigarette smoke induced-bronchial epithelial cell senescence
Source: Annual Congress 2013 –Stress responses and T-cell behaviour in the lung
Year: 2013

PINK1-Parkin pathway-mediated mitophagy is involved in cigarette smoke extract (CSE)-induced cellular senescence in human bronchial epithelial cells (HBEC)
Source: International Congress 2014 – Effect of cigarette smoke on cell behaviour: cell biology, signalling and senescence
Year: 2014

Chaperone-mediated autophagy modulates epithelial cell apoptosis in COPD pathogenesis.
Source: International Congress 2019 – Effects of environmental exposures in lung pathology and the underlying mechanisms
Year: 2019

The capacity of human airway epithelium to regulate T cell proliferation is reduced in asthma
Source: International Congress 2015 – Asthma mechanisms and management
Year: 2015

WNT5A antagonizes canonical WNT/beta-catenin signaling in lung epithelial cells
Source: Annual Congress 2013 –Growth factors at the crossroads of acute and chronic inflammation
Year: 2013

Non-canonical WNT-5A signaling attenuates endogenous lung repair in COPD
Source: International Congress 2016 – New signalling pathways in COPD
Year: 2016

Human lung mast cells alter asthmatic airway epithelial cell function
Source: Annual Congress 2013 –The pulmonary epithelium: recent developments
Year: 2013


Involvement of ferroptosis in COPD pathogenesis
Source: International Congress 2016 – Emerging concepts in lung disease pathogenesis
Year: 2016

Targeting the mTOR signaling pathway to inhibit lung cell senescence in COPD
Source: International Congress 2016 – New signalling pathways in COPD
Year: 2016

Regulation and role of notch signaling in epithelial progenitor cell differentiation and proliferation in the normal and the fibrotic lung
Source: Annual Congress 2013 –Idiopathic pulmonary fibrosis: pathogenesis
Year: 2013

The key role of microRNA-34a in the reduction of sirtuin-1 in COPD
Source: International Congress 2016 – Emerging concepts in lung disease pathogenesis
Year: 2016

Inhibition of IRAK4 suppresses chemokine release from human bronchial epithelial cells
Source: Annual Congress 2013 –Molecular biology: state-of-the-art 2013
Year: 2013

Late Breaking Abstract - WNT/ß-catenin signaling induces cellular senescence in lung alveolar epithelial cells
Source: International Congress 2019 – Oxidative stress, hypoxia and microbial exposure in the pathogenesis of pulmonary disease
Year: 2019

Mitochondrial function in three different types of airway epithelial cells
Source: International Congress 2015 – Translational studies in airway cell biology
Year: 2015


Mitochondrial antioxidants decrease oxidative stress and inflammation induced bronchial epithelial cell line
Source: International Congress 2016 – Studies in airway cell biology
Year: 2016


TGFβ-induced epithelial to mesenchymal transition (EMT) as a model of COPD
Source: International Congress 2016 – Novel insights into alveolar and bronchial epithelial cell injury and repair
Year: 2016

Cigarette smoke modulates the PKAc-associated cross-coupling between NF-kB and glucocorticoid receptor in primary small airway epithelial cells
Source: Annual Congress 2013 –The pulmonary epithelium: recent developments
Year: 2013

Differential expression of uPAR in cultured bronchial epithelial cells from asthma patients
Source: International Congress 2015 – Translational studies in airway cell biology
Year: 2015