Targeting the hedgehog/GLI pathway decreases bleomycin-induced lung fibrosis

E. Farrokhi Moshai, L. Wemeau-Stervinou, N. Cigna, J. Marchal-Somme, V. Besnard, S. Brayer, A. Fabre, A. Mailleux, B. Crestani (Paris, France)

Source: Annual Congress 2013 –Translational studies in chronic repair and remodelling in the lung
Session: Translational studies in chronic repair and remodelling in the lung
Session type: Oral Presentation
Number: 3329
Disease area: Interstitial lung diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
E. Farrokhi Moshai, L. Wemeau-Stervinou, N. Cigna, J. Marchal-Somme, V. Besnard, S. Brayer, A. Fabre, A. Mailleux, B. Crestani (Paris, France). Targeting the hedgehog/GLI pathway decreases bleomycin-induced lung fibrosis. Eur Respir J 2013; 42: Suppl. 57, 3329

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Regulation of autophagy in amiodarone induced pulmonary fibrosis
Source: Annual Congress 2013 –The vulnerable patient and ageing cells
Year: 2013

Thymosin beta4 protects mice from bleomycin-induced damage in the lung
Source: Annual Congress 2013 –Idiopathic pulmonary fibrosis: clinical view
Year: 2013

Arginase 1 contributes to fibrogenesis in the lungs of silica-challenge mice
Source: International Congress 2015 – Pulmonary fibrosis: mechanisms of disease
Year: 2015


Nintedanib reduces bleomycin-induced lung inflammation and fibrosis in mice
Source: Annual Congress 2013 –Preclinical models for the development of new drugs for respiratory diseases
Year: 2013


Resveratrol regulates ECM remodeling in lung fibrosis
Source: International Congress 2014 – New and old players in fibrotic lung disease
Year: 2014

Specialized-proresolving mediators and trancriptomic signatures in bleomycin-induced lung fibrosis
Source: International Congress 2016 – Common mechanisms in lung development and fibrosis
Year: 2016

A transient receptor potential melastin-2 deficiency significantly worsens the fibrotic response to bleomycin in mice
Source: Annual Congress 2013 –The role of hormones and cytokines in lung injury
Year: 2013

Metalloproteases gene expression and remodeling of lung parenchyma fibers during the progression of elastase induced emphysema
Source: International Congress 2014 – Mechanisms of COPD and inhalation injury
Year: 2014


Collagen V activation and matrix extracellular remodeling mediated pulmonary fibrosis in experimental models of bleomycin and 3-5-di-tert-4-hidroxitoluene
Source: Annual Congress 2013 –Growth factors at the crossroads of acute and chronic inflammation
Year: 2013

Inhalation of chlorine causes lung inflammation and airway hyperresponsiveness in a rat model of chemical-induced lung injury
Source: International Congress 2015 – Inflammation and remodelling in lung disease
Year: 2015

17(R)-resolvin D1 ameliorates bleomycin-induced pulmonary fibrosis in mice via decreasing MCP-1 mRNA
Source: International Congress 2015 – Interstitial lung diseases II
Year: 2015


Comparison of expression of napsin A and surfactant protein D in bleomycin-induced pulmonary fibrosis mouse model
Source: Annual Congress 2013 –Diffuse parenchymal lung disease I
Year: 2013

Matrix metalloproteinase-2 is protective in bleomycin-induced pulmonary fibrosis
Source: International Congress 2015 – Animal studies of asthma and other inflammatory conditions
Year: 2015

CD39 deficiency results in increased inflammation in an animal model of pulmonary fibrosis
Source: International Congress 2014 – New and old players in fibrotic lung disease
Year: 2014

Protective effects of Dengzhanshengmai capsules on bleomycin-induced pulmonary fibrosis in mice
Source: International Congress 2014 – ILDs 3
Year: 2014

Treprostinil administration attenuates bleomycin-induced lung fibrosis in mice
Source: International Congress 2015 – Interstitial lung diseases II
Year: 2015

Promotion of lung cancer progression by COPD-like chronic inflammation in a mouse model
Source: Annual Congress 2013 –Basic research on lung cancer
Year: 2013

Olodaterol attenuates bleomycin induced lung fibrosis in mice
Source: International Congress 2016 – Airway pharmacology: drug targets and mode of action
Year: 2016


Late Breaking Abstract - PRRX1 inhibition decreases fibrosis in the bleomycin-induced lung fibrosis model in mice
Source: International Congress 2018 – Regenerative and anti-fibrotic approaches
Year: 2018


PBI-compound, a novel first-in-class anti-fibrotic compound, reduces lung fibrosis in the bleomycin-induced lung fibrosis model: A comparative study with pirfenidone
Source: Annual Congress 2013 –Preclinical models for the development of new drugs for respiratory diseases
Year: 2013