Source: Annual Congress 2013 –Respiratory and cardiovascular abnormalities in COPD: the role of exercise, nutritional status and inflammation
Disease area: Airway diseases

Abstract

Background: Bronchodilators have been reported to influence regional lung ventilation in patients with COPD, which may change regional lung sound distribution. Vibration response imaging (VRI) is a lung imaging system for the assessment of breath sounds.
Objective: To evaluate the effects of a short-actingbeta2-agonist (SABA) on pulmonary functions and the regional distribution of lung sounds in COPD patients.
Methods: A double-blind crossover trial was performed to compare the treatment of COPD patients with a SABA (20 µg of inhaled procaterol) versus a placebo. The percentage of regional lung sound energy (quantitative lung data [QLD]) was evaluated with VRI. VRI, spirometry and impulse oscillometry (IOS) were performed immediately before and 30 minutes after SABA administration.
Results: Ten male patients (69.6±14.2 years of age, percentage predicted FEV1: 43.8±16.9%) were evaluated. The use of a SABA produced significant functional improvements in the spirometric and IOS measurements. Among the homogeneous emphysema patients (n=7), the upper-lung QLD decreased (24.2±5.8% to 18.8±6.1%, p<0.05) and the lower-lung QLD increased (37.9±12.7% to 46.1±14.3%, p<0.05) following SABA inhalation. However, the significant redistribution of the regional lung QLD to the lower lung field was not observed in two of the three inhomogeneous emphysema patients.
Conclusion: The additional use of a SABA by COPD patients improved their pulmonary function, which was accompanied by changes in regional lung air flow. The distribution of the emphysematous lesion and the bronchial reactivity to SABA appeared to affect the redistribution of the lung sounds following bronchodilator administration.

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Citations should be made in the following way:
M. Mineshita, S. Matsuoka, T. Miyazawa (Kawasaki, Japan). The effects of bronchodilators on regional lung sound distribution in patients with COPD. Eur Respir J 2013; 42: Suppl. 57, 2505

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