Source: Annual Congress 2003 - Clinical features in tuberculosis - I

Abstract

We investigated the oxidative stress induced by tuberculostatic continuous treatment in 23 patients and 10 normal persons as controls by spectrophotometrical determinations of superoxid dismutase (SOD) and gluthation (GSH) levels in heparinised blood and urine. The tests were performed in basal condition and after 2 and 4 weeks of treatment.
The plasma SOD values determinated in basal condition were significantly increased than in controls (p<0.05), than after 2 weeks (p=0.03) of treatment and insignificantly increased (p=0.5) than after 4 weeks. Urine SOD values in basal condition were increased (p=0.003) than in controls. Urine SOD values determinated after 2 weeks (p=0.01) and 4 weeks of treatment were significantly decreased than in basal condition. Plasma GSH values in patients, in basal condition, were decreased (p<0.0001) than in controls. After 2 weeks of treatment, plasma GSH values were increased (p<0.0001) than in basal condition and after 4 weeks retourn at about basal values. Urine GSH values in basal condition were decreased than in controls (p<0.0001), significantly increased after 2 weeks of treatment than in basal condition and insignificantly decreased at 4 weeks.
The values of SOD and GSH in patients showed un increased oxidative stress due by inflammatory processes. After 2 weeks of treatment the values indicated transient tissue injuries, and after 4 weeks, the decreased values indicated the setting up of adaptation processes.

Rating:

Share or cite this content

Citations should be made in the following way:
D. M. Cocarla, L. M. Munteanu (Timisoara, Romania). The oxidative stress determination on patients trated with tuberculostatic drugs. Eur Respir J 2003; 22: Suppl. 45, 1000

Member's Comments

No comment yet.

Related content which might interest you: The renal oxidative stress induced by tuberculostatic treatment correlated with nephrotoxic markers Source: Eur Respir J 2004; 24: Suppl. 48, 649s Year: 2004 Theophylline is a more effective anti-inflammatory agent under conditions of oxidative stress Source: Eur Respir J 2003; 22: Suppl. 45, 38s Year: 2003 The nephrotoxic effect assesment of tuberculostatic drugs therapy by urinary enzymes Source: Eur Respir J 2004; 24: Suppl. 48, 654s Year: 2004 The effect of one-night CPAP therapy on oxidative stress and anti-oxidant defense in patients with severe OSA Source: Annual Congress 2010 - Biomarkers for oxidative stress, inflammation and cardiovascular function in sleep apnoea Year: 2010 Influence of oxygen therapy on oxidative stress parameters in severe COPD patients Source: Eur Respir J 2002; 20: Suppl. 38, 234s Year: 2002 Vasodilator therapy, exercise tolerance and oxidant stress in IPF patients Source: Eur Respir J 2007; 30: Suppl. 51, 111s Year: 2007 The influence of N-acetylcysteine on oxidative stress in patients with COPD Source: Annual Congress 2010 - Novel insights into the pathophysiology of asthma and COPD Year: 2010 Effect of pulmonary rehabilitation on erythrocyte oxidative stress and antioxidants in COPD patients Source: Annual Congress 2012 - The best posters on physical inactivity, muscle dysfunction and exercise intolerance Year: 2012 Effectiveness of N-acetylcysteine in correction of oxidative stress in combined therapy in patients with severe bronchial asthma Source: Annual Congress 2007 - Traditional and novel approaches to assess and achieve asthma control Year: 2007 High doses of N-acetylcysteine alone or in combination with inhaled corticosteroids and oxidative stress in patients with COPD Source: Annual Congress 2011 - Novel mechanisms in lung injury Year: 2011 Neutrophils and oxidative stress markers may be a useful indicator for initiating chemotherapy in NTM patients Source: International Congress 2019 – Mechanisms underlying respiratory infection Year: 2019 The effect of CPAPn treatment in oxidative stress in patients with SAHS Source: Eur Respir J 2006; 28: Suppl. 50, 574s Year: 2006 Increased oxidative stress and altered antioxidant status in Chinese patients with COPD Source: Eur Respir J 2004; 24: Suppl. 48, 62s Year: 2004 The effect of phosphogliv admission on non-invasive oxidative stress markers in patients with bronchial asthma Source: Eur Respir J 2006; 28: Suppl. 50, 208s Year: 2006 Indicators of oxidative stress of COPD patients Source: Annual Congress 2008 - Structural remodelling in COPD Year: 2008 Serum paraoxonase, oxidative stress index and total antioxidant capacity in asthmatic children before and after treatment with inhaled corticosteroid Source: Eur Respir J 2005; 26: Suppl. 49, 616s Year: 2005 The dietary antioxidant quercetin reduces markers of oxidative stress and inflammation in sarcoidosis Source: Eur Respir J 2007; 30: Suppl. 51, 110s Year: 2007 Oxidative stress in patients with asthma Source: Eur Respir J 2001; 18: Suppl. 33, 43s Year: 2001 Drug-induced pulmonary toxicity: a role for anti-oxidants in oxidative stress Source: Annual Congress 2009 - PG7 Drug-induced pulmonary toxicity Year: 2009 The effects of antioxidant therapy on lung clearance, pulmonary function test and oxidant stress in patients with COPD Source: Eur Respir J 2002; 20: Suppl. 38, 258s Year: 2002