Roflumilast and its active metabolite roflumilast N-oxide do not interact with R- and S-warfarin

B. Hauns, A. Huennemeyer, L. Duursema, D. Hauschke, K. Zech, J. Terblanché, L. Venter, T. D. Bethke (Konstanz, Germany; Bloemfontein, Rivonia, South Africa)

Source: Annual Congress 2003 - Non-steroidal drugs in the treatment of respiratory diseases
Session: Non-steroidal drugs in the treatment of respiratory diseases
Session type: Thematic Poster Session
Number: 717

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
B. Hauns, A. Huennemeyer, L. Duursema, D. Hauschke, K. Zech, J. Terblanché, L. Venter, T. D. Bethke (Konstanz, Germany; Bloemfontein, Rivonia, South Africa). Roflumilast and its active metabolite roflumilast N-oxide do not interact with R- and S-warfarin. Eur Respir J 2003; 22: Suppl. 45, 717

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Pharmacokinetics of roflumilast and its active metabolite roflumilast N-oxide are not influenced by erythromycin
Source: Eur Respir J 2004; 24: Suppl. 48, 128s
Year: 2004

Effect of ketoconazole on the pharmacokinetics of roflumilast and roflumilast N-oxide
Source: Eur Respir J 2006; 28: Suppl. 50, 435s
Year: 2006

Effects of steady-state enoxacin on single-dose pharmacokinetics of roflumilast and roflumilast N-oxide
Source: Annual Congress 2009 - New bronchodilators
Year: 2009


Effects of steady-state female hormones on single-dose pharmacokinetics of roflumilast and roflumilast N-oxide
Source: Annual Congress 2011 - Drug delivery and pharmacokinetics II
Year: 2011


‘Total PDE4 inhibitory activity‘: a concept for evaluating pharmacokinetic alterations of roflumilast and roflumilast N-oxide in special populations and drug-drug interactions
Source: Eur Respir J 2006; 28: Suppl. 50, 436s
Year: 2006

Pharmacokinetic characteristics of roflumilast and its active metabolite roflumilast-N-oxide are not affected by food intake
Source: Eur Respir J 2002; 20: Suppl. 38, 109s
Year: 2002

Pharmacokinetics of roflumilast and roflumilast N-oxide in healthy subjects after a single, oral dose of 500µg roflumilast in the morning versus evening
Source: Eur Respir J 2003; 22: Suppl. 45, 102s
Year: 2003

Equivalent pharmacokinetics of the active metabolite of ciclesonide when using the ciclesonide-MDI with and without a spacer
Source: Eur Respir J 2004; 24: Suppl. 48, 583s
Year: 2004

Smoking has no effect on the pharmacokinetics of roflumilast, a new, orally active, selective PDE4 inhibitor
Source: Eur Respir J 2001; 18: Suppl. 33, 156s
Year: 2001

High oral absolute bioavailability of roflumilast, a new, orally active, once daily PDE4 inhibitor
Source: Eur Respir J 2001; 18: Suppl. 33, 20s
Year: 2001

No interaction of roflumilast, a new, orally active, selective PDE4 inhibitor, with inhaled salbutamol
Source: Eur Respir J 2001; 18: Suppl. 33, 156s
Year: 2001

Effect of CYP3A4 inhibitors verapamil and itraconazole on the pharmacokinetics of AZD7986, an oral DPP1 inhibitor
Source: International Congress 2017 – Asthma management
Year: 2017


Pharmacokinetics of roflumilast and its active metabolite roflumilast-N-oxide in middle aged and young subjects
Source: Eur Respir J 2002; 20: Suppl. 38, 109s
Year: 2002

Roflumilast, a new, orally active, selective PDE4 inhibitor, does not interact with inhaled budesonide
Source: Eur Respir J 2001; 18: Suppl. 33, 156s
Year: 2001

Roflumilast N-oxide, a selective PDE4 inhibitor, curbs platelet-leukocyte interactions
Source: Annual Congress 2011 - Translational models of disease
Year: 2011


Roflumilast N-oxide reduces human fibroblast function
Source: Annual Congress 2007 - Miscellaneous pulmonary pharmacology
Year: 2007


Angiogenic activity of NSCLC cells is inhibited by sulindac and sulphone metabolite of sulindac
Source: Eur Respir J 2001; 18: Suppl. 33, 234s
Year: 2001

Comparison of pharmacological and pharmacokinetic properties of levocetirizine and dextrocetirizine, the (R) and (S) enantiomers of cetirizine
Source: Eur Respir J 2004; 24: Suppl. 48, 129s
Year: 2004

Influence of food intake on the pharmacokinetics of roflumilast, a new, orally active, selective PDE4 inhibitor
Source: Eur Respir J 2001; 18: Suppl. 33, 42s
Year: 2001

First-dose bronchodilating effect of phosphodiesterase-4 (PDE-4) inhibition by cilomilast (Ariflo) with or without coadministration of salbutamol and/or ipratropium in COPD patients
Source: Eur Respir J 2001; 18: Suppl. 33, 35s
Year: 2001