Modification of gene expression and increase in alpha-1-antitrypsin (α1 AT) secretion after homologous recombination in α1 AT deficient monocytes Source: Annual Congress 2007 - Inflammatory cell biology Year: 2007
Alteration of ROS metabolism and cell type-specific differentiation markers in the lungs of Pex11β (-/-) mice, a mouse model deficient in peroxisome proliferation Source: Annual Congress 2008 - Cell biology of asthma and COPD Year: 2008
Nuclear expression of Ku86, a DNA repair protein, is decreased in bronchiolar epithelium of COPD patients Source: Eur Respir J 2004; 24: Suppl. 48, 458s Year: 2004
Nasal tolerance promotes increase in tumoral type V collagen protein synthesis and vascular apoptosis in the mouse lung chemical carcinogenesis Source: Annual Congress 2010 - Novel cellular mechanisms in lung disease Year: 2010
Hypoxia-induced methylation of the Thy-1 promoter is associated with transcriptional repression in human primary lung fibroblasts Source: Annual Congress 2010 - Recent developments of molecular pathology and functional genomics in non-neoplastic and neoplastic lung diseases Year: 2010
TGF-beta-dependent inhibitor of DNA protein (Id) expression in lung fibrosis Source: Eur Respir J 2006; 28: Suppl. 50, 521s Year: 2006
DNA methylation and gene expression changes in human lung fibroblasts occur already in mild COPD and progress with disease development Source: International Congress 2018 – Functional genomics and COPD: new challenges Year: 2018
Decreased expression of FENDRR, a lung mesenchymal long non-coding RNA, regulates fibroblast phenotypes in IPF through NOX4. Source: International Congress 2017 – Functional genomics knowledge in parenchymal and bronchial diseases Year: 2017
Upregulated HIF (hypoxia inducible factor)-1 DNA binding activity to VEGF-a promoter mediates oedema formation in donor lung grafts Source: Eur Respir J 2003; 22: Suppl. 45, 7s Year: 2003
Low expression of cellular retinoic acid binding protein 2 and dysregulation of elastin expression in pulmonary emphysema fibroblasts Source: Annual Congress 2008 - Structural remodelling in COPD Year: 2008
Nanoparticle-driven DNA damage mimics irradiation by inducing growth arrest and phosphorylation of 53BP-1, BRCA1 and H2A.X Source: Eur Respir J 2006; 28: Suppl. 50, 620s Year: 2006
Nanoparticle-driven DNA damage mimics irradiation-related carcinogenesis pathways Source: Eur Respir J 2008; 31: 241-251 Year: 2008
High-capacity adenoviral vectors for gene transfer: reduced toxicity and reduced cell-cycle dysregulation Source: Eur Respir J 2002; 20: Suppl. 38, 14s Year: 2002
PTEN deficiency in alveolar type 2 cells accelerates cellular senescence, disrupts epithelial–mesenchymal and mitochondrial homeostasis, and induces age-related emphysema Source: International Congress 2019 – Cellular metabolism and immune senescence in lung pathology Year: 2019
High proteasome activity and absence of NF-kB activation in cystic fibrosis cell culture and CF KO mouse models in response to oxidative stress Source: Eur Respir J 2005; 26: Suppl. 49, 403s Year: 2005
Prolyl-3-hydroxylase 4 (P3H4), a novel player in collagen synthesis and secretion in lung fibroblasts Source: Virtual Congress 2021 – Translational and other aspects of idiopathic interstitial pneumonia Year: 2021
The RNA binding protein HuR regulates the senescence-associated secretory phenotype under conditions of oxidative stress Source: International Congress 2019 – Identification of new targets and therapeutic strategies for lung disease Year: 2019
PP221 – EZH2-dependent transcriptional complex promotes aberrant epithelial remodelling after injury Source: ERS Lung Science Conference 2021 Year: 2021
Dysregulated mitochondrial integrity associated with lamin B1 reduction is involved in cellular senescence progression in COPD pathogenesis. Source: International Congress 2018 – New kids on the block: novel molecular pathways and therapeutic targets in chronic lung diseases Year: 2018