Source: Annual Congress 2003 - Respiratory structure and mechanisms: current concepts
Disease area: Airway diseases

Abstract

Guinea pig airways are innervated by vagal sensory fibers derived from neurons in the nodose and jugular ganglia. Embryologically, the nodose ganglia are derived from the epibranchial placodes, whereas the jugular ganglia are neural crest in origin. About 90% of the nociceptive C-fibers in the trachea-bronchus were found to be jugular fibers, with the nodose neurons projecting mainly low-threshold mechanosensing Aδ fibers (Riccio et al., J. Physiol. 496:521-30, 1996). An in vitro preparation was used to investigate C-fibers (c.v. <1.0 m/s) with receptive fields within the lungs. By contrast to the extrapulmonary airways, both the nodose and jugular ganglion neurons projected C-fibers to the lungs. All C-fibers (n=55) responded to capsaicin (1 µM) application. The vast majority of jugular C-fibers in the lungs were unresponsive to ATP. By contrast 100% of the nodose C-fibers responded vigorously to 30 µM ATP. Likewise, patch clamp studies revealed that lung labeled jugular neurons were nearly unresponsive to ATP, whereas lung labeled nodose neurons responded to ATP with ~5 nA inward current. Histologically, jugular C-fiber neurons were nearly uniformly substance P -positive, whereas most nodose C-fiber neurons were substance P-negative. Our data indicate that capsaicin-sensitive vagal C-fibers in the airways comprise at least two distinct phenotypes. The question remains as to whether activation of nodose C-fibers leads to different reflex physiology than that initiated by the tachykinergic jugular C-fiber population. Supported by NIH (USA).

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B. J. Undem, E. J. Oh, M. G. Lee, D. Weinreich, K. Marian (Baltimore, United States Of America). Two distinct phenotypes of pulmonary vagal sensory C-fibers. Eur Respir J 2003; 22: Suppl. 45, 167

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