Source: Annual Congress 2003 - Respiratory structure and mechanisms: current concepts
Disease area: Airway diseases, Respiratory critical care

Abstract

Total respiratory impedance (Zrs) between 4 and 38 Hz was estimated continuously during slow TLC manoeuvres in 6 anesthetized and mechanically ventilated BALB/c mice. Zrs was measured with pseudorandom forced oscillations by means of the wave tube technique during inflation from a transrespiratory pressure of 0 to 20 hPa and subsequent deflation, each lasting for ~20 s. Zrs was averaged for 0.5 s intervals and fitted by a model including airway resistance (Raw) and inertance, and tissue damping and elastance (H). The interdependence of Raw and H was split into two distinct and closely linear trajectories for the low- and high-volume regions, which were separated at ~40% of the inspiratory capacity and characterized by high correlation coefficients (r²= 0.953±0.025 and 0.835±0.059, respectively). The Raw vs H relationship in the low-volume region, which differed slightly for the inspiratory and the expiratory data (mean slope: 0.0137±0.0020 s), can be interpreted in terms of recruitment and closure of airspaces and/or tissue non-linearities, whereas the high-volume relationship (mean slope: -0.00088±0.00016 s) expresses the relative distensibility of the airway and tissue compartments. - Supported by grants T30670 OTKA, Hungary, and 211912 and 10199 NH&MRC, Australia.

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Z. Hantos, R. A. Collins, D. J. Turner, T. Z. Jánosi, P. D. Sly (Szeged, Hungary; Perth, Australia). Interdependence of airway and tissue mechanics during TLC manoeuvres in mice. Eur Respir J 2003; 22: Suppl. 45, 164

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