Effect of recombinant α-1 antitrypsin (rAAT) and TAPI on neutrophil elastase (NE) and matrix metalloproteinase-9 (MMP9) activity in induced sputum (IS) from healthy smokers and patients with chronic obstructive pulmonary disease (COPD)

J. R. Topping, E. J. Vanden Bon, R. C. Tennant, T. T. Hansel, P. J. Barnes, P. J. Barr, P. A. Pemberton, D. J. Sundin, T. D. Tetley (London, United Kingdom; Alameda)

Source: Annual Congress 2003 - Progress on therapy for chronic obstructive pulmonary disease
Session: Progress on therapy for chronic obstructive pulmonary disease
Session type: Oral Presentation
Number: 159
Disease area: Airway diseases

Congress or journal article abstractSlide presentation

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
J. R. Topping, E. J. Vanden Bon, R. C. Tennant, T. T. Hansel, P. J. Barnes, P. J. Barr, P. A. Pemberton, D. J. Sundin, T. D. Tetley (London, United Kingdom; Alameda). Effect of recombinant α-1 antitrypsin (rAAT) and TAPI on neutrophil elastase (NE) and matrix metalloproteinase-9 (MMP9) activity in induced sputum (IS) from healthy smokers and patients with chronic obstructive pulmonary disease (COPD). Eur Respir J 2003; 22: Suppl. 45, 159

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Human macrophage elastase (MMP-12) expression in human emphysematous lungs: role in extracellular matrix remodelling in chronic obstructive pulmonary diseases (COPD)
Source: Eur Respir J 2001; 18: Suppl. 33, 501s
Year: 2001

Elevation of neutrophil collagenase (MMP-8) and elastase during COPD exacerbation
Source: Annual Congress 2008 - Inflammatory trigger mechanisms in asthma and COPD
Year: 2008


Concentration of NO2-, a-acid protein (AAP), tumor necrotic factor (TNF-a), in the induced sputum of patients with bronchial asthma(BA) and chronic obstructive bronchitis (COB)
Source: Eur Respir J 2001; 18: Suppl. 33, 367s
Year: 2001

Relationship between circulating serpina 3g, activity of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1, 2 with chronic obstructive pulmonary disease severity
Source: International Congress 2018 – Studying novel biomarkers in asthma and COPD
Year: 2018

Increased serum concentrations of tissue inhibitor of metalloproteinase-1 in COPD patients
Source: Eur Respir J 2005; 25: 885-890
Year: 2005



Relationship between Candida strains colonization and MMP-9 and TIMP-1 induced sputum concentration in chronic obstructive pulmonary disease‘s (COPD) patients and healthy control group
Source: Annual Congress 2010 - Colonisation and infection in COPD
Year: 2010

Relationship between MMP-9 and TIMP-1 induced sputum concentration and the stage of chronic obstructive pulmonary disease‘s (COPD)
Source: Annual Congress 2008 - Issues in the management of COPD in the community
Year: 2008

The effect of sputum processing on tumour necrosis factor (TNFα), secretory leukoprotease inhibitor (SLPI), interleukin-6 and leukotriene-B4 (LTB4) in chronic bronchitis and bronchiectasis
Source: Eur Respir J 2001; 18: Suppl. 33, 364s
Year: 2001

The expression of MMP2, 9 and TIMP1 mRNA in bronchoalveolar cells of patients with chronic obstructive pulmonary disease (COPD) and bronchial asthma
Source: Annual Congress 2009 - New results in molecular pathology and functional genomics of non-neoplastic lung diseases
Year: 2009

Impact of acute exposure to tobacco smoke on gelatinases in the bronchoalveolar space
Source: Eur Respir J 2008; 32: 644-650
Year: 2008



Matrix metalloproteinases (MMPs), tissue inhibitor of matrix metalloproteinases (TIMPs) and transforming growth factor-β (TGFβ) expression in small airways (SA) of usual idiopathic pneumonia (UIP), non-specific interstitial pneumonia (NSIP), hip
Source: Annual Congress 2007 - Role of genomics and biological tools in the work-up of interstitial lung disease
Year: 2007


Production of matrix metalloprotease-9 (MMP-9) by alveolar macrophages (AMs) from smokers: effect of corticosteroids and phosphodiesterase inhibition
Source: Eur Respir J 2001; 18: Suppl. 33, 34s
Year: 2001

Inhibition of elastinolytic activity in induced sputum from COPD patients and healthy controls by recombinant alpha 1-antitrypsin (rAAT) and a fusion protein, TAPI
Source: Eur Respir J 2004; 24: Suppl. 48, 471s
Year: 2004

MMP2, 8, 9 and TIMP1-4 levels in bronchoalveolar fluid of patients with chronic obstructive pulmonary disease and bronchial asthma
Source: Annual Congress 2010 - Mechanisms and modulation of allergic inflammation in the lung
Year: 2010


Measurement of tumor necrosis factor (TNF)α, leukotriene B4 (LTB4), and interleukin 8 (IL8) in the exhaled breath condensate (EBC) in patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD)
Source: Eur Respir J 2007; 30: Suppl. 51, 584s
Year: 2007

Increased levels of human myeloperxidase (MPO) and neutrophil lipocalin (HNL/NGAL) in childhood asthma
Source: International Congress 2019 – Understanding, monitoring and targeting severe asthma
Year: 2019


Increased expression of phosphodiesterase 4 (PDE4) A, B and D in alveolar macrophages from chronic obstructive pulmonary disease (COPD) patients
Source: Annual Congress 2011 - Macrophages and neutrophils in chronic lung disease
Year: 2011


Enhanced expression of proinflammatory cytokine (IL-18) and its receptor in patients with chronic obstructive pulmonary disease (COPD)
Source: Eur Respir J 2006; 28: Suppl. 50, 551s
Year: 2006

Increased neutrophil gelatinase-associated lipocalin (NGAL) promotes airway remodeling in chronic obstructive pulmonary disease (COPD)
Source: International Congress 2016 – Laboratory tests and cell biology in allergy and immunology
Year: 2016

Proteinase 3 activity in sputum from subjects with alpha-1-antitrypsin deficiency and COPD
Source: Eur Respir J 2013; 41: 1042-1050
Year: 2013