LATE-BREAKING ABSTRACT: Coagulation factor IX deficiency does not afford protection from pulmonary fibrosis in the experimental murine bleomycin model

K. Borensztajn, L. Cong, B. Crestani, O. Christophe, A. Spek (Paris, Le Kremlin-Bicêtre, France; Amsterdam, Netherlands)

Source: Annual Congress 2012 - Diffuse parenchymal lung disease IV
Session: Diffuse parenchymal lung disease IV
Session type: Thematic Poster Session
Number: 3670
Disease area: Interstitial lung diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
K. Borensztajn, L. Cong, B. Crestani, O. Christophe, A. Spek (Paris, Le Kremlin-Bicêtre, France; Amsterdam, Netherlands). LATE-BREAKING ABSTRACT: Coagulation factor IX deficiency does not afford protection from pulmonary fibrosis in the experimental murine bleomycin model. Eur Respir J 2012; 40: Suppl. 56, 3670

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Inhalation of activated recombinant factor VII to treat pulmonary hemorrhage in a patient with cystic fibrosis
Source: Annual Congress 2011 - Acute respiratory failure
Year: 2011

Erythropoietin (EPO) inhibits the bleomycin (BLM)-induced pulmonary fibrosis in rats
Source: Annual Congress 2010 - Emerging mechanisms in lung injury
Year: 2010

Electroporation mediated gene transfer of hepatocyte growth factor reduces bleomycin induced pulmonary fibrosis
Source: Eur Respir J 2005; 26: Suppl. 49, 729s
Year: 2005

The effect of tenascin-c deficiency on TGF-β-mediated fibrosis and alveolar inflammation in a murine model of ARDS
Source: Annual Congress 2009 - Pathological remodelling in chronic lung disease: from epithelial-mesenchymal transition to cellular activation
Year: 2009


The attenuating effect of erythropoietin (EPO) on the expression of myeloperoxidase (MPO) in bleomycin-induced pulmonary fibrosis in rats
Source: Annual Congress 2013 –The role of hormones and cytokines in lung injury
Year: 2013

Collagen V activation and matrix extracellular remodeling mediated pulmonary fibrosis in experimental models of bleomycin and 3-5-di-tert-4-hidroxitoluene
Source: Annual Congress 2013 –Growth factors at the crossroads of acute and chronic inflammation
Year: 2013

A transient receptor potential melastin-2 deficiency significantly worsens the fibrotic response to bleomycin in mice
Source: Annual Congress 2013 –The role of hormones and cytokines in lung injury
Year: 2013

Antithrombin plus alpha–1 protease inhibitor does not affect pulmonary inflammation and coagulation in a ‘double-hit’ lung injury model
Source: International Congress 2018 – Preclinical and clinical studies of critical illness
Year: 2018


LATE-BREAKING ABSTRACT: KCa3.1 ion channel-blockade reduces pulmonary fibrotic responses via the inhibition of fibroblast proliferation
Source: International Congress 2016 – Common mechanisms in lung development and fibrosis
Year: 2016

Attenuation of bleomycin-induced pulmonary fibrosis by direct thrombin inhibition is accompanied by a reduction in connective tissue growth factor mRNA levels
Source: Eur Respir J 2001; 18: Suppl. 33, 199s
Year: 2001

The effects of erdosteine and N-acetylcysteine treatment following lung injury on the regulation of apoptosis of capillary endothelial cells in the model of experimental pulmonary fibrosis induced by bleomycin
Source: Annual Congress 2008 - Airway cell biology and immunology
Year: 2008

LATE-BREAKING ABSTRACT: Aggravation of bleomycin-induced pulmonary fibrosis in senescence-accelerated mouse
Source: Annual Congress 2012 - Diffuse parenchymal lung disease IV
Year: 2012

Erythropoietin (EPO) attenuates the immunohistochemical expression of tumor growth factor-ß (TGF-ß) in bleomycin (BLM)-induced pulmonary fibrosis (PF) in rats
Source: International Congress 2018 – Pulmonary fibrosis: from models to patients
Year: 2018

Coagulation factor XII regulates inflammatory responses in human lungs
Source: International Congress 2017 – Anti-inflammatory and pro-repair mediators in acute lung injury
Year: 2017

Regulation, cell-specific expression and metabolism of factor VII activating protease (FSAP) in lungs from patients with acute respiratory distress syndrome (ARDS) and idiopathic pulmonary fibrosis (IPF)
Source: Eur Respir J 2006; 28: Suppl. 50, 823s
Year: 2006

Role of Bcl-xL in hepatocyte growth factor elicited epithelial protection in idiopathic lung fibrosis
Source: Annual Congress 2013 –Idiopathic pulmonary fibrosis: pathogenesis
Year: 2013

Angiotensin II antagonism fails to ameliorate bleomycin-induced pulmonary fibrosis in mice
Source: Eur Respir J 2005; 25: 708-714
Year: 2005



Overexpression of hypoxia-inducible factor (HIF)-1α in ischemia/reperfusion injury developed in a lung transplantation model
Source: International Congress 2016 – Post-transplant complications: from animal models to the bedside
Year: 2016


LATE-BREAKING ABSTRACT: Amelioration of hyperoxia-induced lung injury in newborn mice using a sphingolipid-based intervention
Source: Annual Congress 2012 - Lung injury and repair: reactive oxygen species and beyond
Year: 2012