Source: Annual Congress 2012 - Predicting and observing paediatric allergic disease
Disease area: Airway diseases, Paediatric lung diseases

Abstract

Asthma is a chronic inflammatory disease of the airways. Allergen-specific immunotherapy is the unique disease modifying treatment of atopic diseases. SLIT is effective treatment associated with low incidence of systemic reactions. A disturbed T cells apoptosis plays a crucial role in the in the development of airway inflammation in the course of asthma. Nevertheless, the effect of sublingual immunotherapy on T cell apoptosis has not been elucidated. The aim of present study was to evaluate the influence of one year allergen-specific immunotherapy in asthmatic children on the frequency of Th1 Bcl-2 positive cells in peripheral blood.
Twenty-five children, suffering from bronchial asthma and allergic rhinitis were enrolled to the study. Children were shortlisted for sublingual specific immunotherapy with solution containing specific allergen (grass pollen or house dust mite) extracts. The frequency of Th1 cells and the intracellular expression of Bcl-2 were evaluated using flow cytometry before and after 12 months of treatment. The frequency of Th1 cells after immunotherapy was significantly increased (13,22 [10,34; 18,95]% before versus 19,86 [16,37; 24,52]% after SLIT, p=0.01), moreover significant increase of Bcl-2 positive Th1 cells was found after treatment. At a baseline 58,34 (31,23; 76,28) % of Th1 cells showed expression of Bcl-2 protein, whereas 73,61 (68,47; 82,43) % Th1 cells expressed Bcl-2 after one year of SLIT, p= 0.0465.
The increase of Th1 cells frequency secondary to SLIT might be associated with enhanced resistance to apoptotic signals. However, further studies are needed to clarify the role of T cell apoptosis in resolution of allergic airway inflammation.

Rating:

Share or cite this content

Citations should be made in the following way:
O. Ciepiela, A. Zawadzka-Krajewska, I. Kotula, U. Demkow (Warsaw, Poland). The impact of sublingual immunotherapy (SLIT) of asthma on Th1 cells susceptibility to apoptosis. Eur Respir J 2012; 40: Suppl. 56, 1940

Member's Comments

No comment yet.

Related content which might interest you: Study of the effect of IL-4 and IFN-γ on Th1/Th2 cells and mast cells in allergic asthma patients Source: Eur Respir J 2001; 18: Suppl. 33, 271s Year: 2001 The influence of the allergen-specific immunotherapy (ASIT) against the backdrop of an immunomodulator in patients suffering from seasonal allergic rhinitis (SAR) on the level of cytokines, IgE and IgG. Source: Virtual Congress 2020 – New insight into the pathogenesis of chronic lung diseases: asthma, COPD and others Year: 2020 Follicular T helper and Breg cell balance in severe allergic asthma before and after omalizumab therapy Source: Virtual Congress 2021 – Pearls in immunology, outcome studies and clinical trials in asthma, alpha-1 antitrypsin deficiency and COPD Year: 2021 Cytokine production profile of T-lymphocytes and frequence of regulatory T-cells in patients with allergic asthma receiving anti-IgE therapy Source: Annual Congress 2011 - Allergen immunotherapy and anti-immunoglobulin E Year: 2011 The role of T-lymphocytes in food allergy and asthma Source: Annual Congress 2005 - Food allergy, atopic dermatitis and asthma Year: 2005 T-cell co-stimulatory molecules: novel targets for the treatment of allergic airway disease Source: Eur Respir J 2007; 30: 383-390 Year: 2007 MiR-1165-3p downregulated in Th2 cells inhibits Th2 differentiation in allergic asthma by targeting PPM1A Source: International Congress 2019 – Identification of new targets and therapeutic strategies for lung disease Year: 2019 IL-33 mRNA in induced sputum cells from allergic rhinitis and asthma patients: a marker of Th-2 phenotype status? Source: International Congress 2017 – Monitoring asthma control Year: 2017 Expression of surface markers on peripheral CD4+CD25high T cells in patients with atopic asthma: role of inhaled corticosteroid Source: Annual Congress 2008 - Risk factors for asthma versus asthma control Year: 2008 Expression of interleukin-4 receptor in bronchial asthma patients treated with specific immunotherapy (SIT) Source: Eur Respir J 2002; 20: Suppl. 38, 589s Year: 2002 CD39/CD73 and the imbalance of Th17 and Tregs (regulatory T cells) in allergic asthma Source: Annual Congress 2013 –Studies of asthma in man Year: 2013 Interferon-γ-pretreated dendritic cells induced dual Th1 and Th2 responses and failed to prevent development of allergic airway inflammation Source: Eur Respir J 2006; 28: Suppl. 50, 230s Year: 2006 Gamma/delta T cells regulate airways disease during rhinovirus-induced asthma exacerbations Source: Annual Congress 2011 - Insight into mechanisms of respiratory infections Year: 2011 The influence of topical glucocorticoid on apoptosis of lymphocytes during allergic rhinitis Source: Annual Congress 2008 - Asthma: mechanisms and treatment Year: 2008 Association between Th2 biomarker levels and efficacy of house dust mite sublingual allergy immunotherapy in adults with allergic asthma Source: Virtual Congress 2021 – Asthma clinical trials and real-life studies Year: 2021 Dendritic cell subsets in the lung: implication for allergic asthma Source: Annual Congress 2006 - A new look at dendritic cell interactions in the lung Year: 2006 T cell resistance to Fas-mediated apoptosis during atopic bronchial asthma (ABA) Source: Eur Respir J 2002; 20: Suppl. 38, 29s Year: 2002 Induction of T cell anergy by high dose allergen in allergic mice and underlying mechanism Source: Annual Congress 2007 - Mouse models of allergic airway inflammation Year: 2007 Allergen immunotherapy induces a suppressor memory response that is mediated by IL-10 in a mouse model of asthma Source: Eur Respir J 2003; 22: Suppl. 45, 194s Year: 2003