Activation of both transcription factors STAT5 and IRF-1 is insensitive to corticosteroids in asthmatic bronchial smooth muscle cells exposed to TNFα/IFNγ

A. Gavrila, L. Chachi, O. Tliba, C. Brightling, Y. Amrani (Leicester, United Kingdom; Philadelphia, United States Of America)

Source: Annual Congress 2012 - Cellular signalling mechanisms in the airways
Session: Cellular signalling mechanisms in the airways
Session type: Poster Discussion
Number: 3416
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
A. Gavrila, L. Chachi, O. Tliba, C. Brightling, Y. Amrani (Leicester, United Kingdom; Philadelphia, United States Of America). Activation of both transcription factors STAT5 and IRF-1 is insensitive to corticosteroids in asthmatic bronchial smooth muscle cells exposed to TNFα/IFNγ. Eur Respir J 2012; 40: Suppl. 56, 3416

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Transcription factor activation and mitogenic synergism in airway smooth muscle cells.
Source: Eur Respir J 2003; 22: 190
Year: 2003


Steroid resistant STAT5 activation by TNFα in airway smooth muscle cells
Source: Eur Respir J 2007; 30: Suppl. 51, 494s
Year: 2007

Compound A modulates steroid insensitive chemokines in airway smooth muscle cells via IRF-1 dependent and independent pathways
Source: International Congress 2015 – New targets and modalities for the treatment of asthma and COPD
Year: 2015

Transcription factor activation and mitogenic synergism in airway smooth muscle cells
Source: Eur Respir J 2003; 21: 759-769
Year: 2003



Transcriptional regulation of CXCL8 hypersecretion in asthmatic airway smooth muscle cells
Source: Annual Congress 2009 - Airway cell biology
Year: 2009


Rhinovirus-induced IL-33 expression in asthmatic airway smooth muscle cells is TLR3-dependent and involves activation of TAK1
Source: International Congress 2016 – Emerging concepts in lung disease pathogenesis
Year: 2016

TLR3/TAK1 signalling regulates rhinovirus-induced interleukin-33 in bronchial smooth muscle cells
Source: ERJ Open Res, 6 (4) 00147-2020; 10.1183/23120541.00147-2020
Year: 2020



Relative corticosteroid insensitivity in human airway smooth muscle cells from severe asthma patients in terms of transrepression not transactivation
Source: Annual Congress 2010 - Airway smooth muscle cells
Year: 2010


Increased activation of TGF-β by asthmatic airway smooth muscle cells via integrin αVβ5
Source: Annual Congress 2009 - Airway cell biology
Year: 2009


Effect of TGF-β on FoxO activity in airway smooth muscle cells
Source: Annual Congress 2012 - Cellular signalling mechanisms in the airways
Year: 2012


Differential CCAAT/enhancer binding protein (C/EBP) isoforms expression in human bronchial smooth muscle cells of asthmatic and COPD patients
Source: Eur Respir J 2004; 24: Suppl. 48, 695s
Year: 2004

Budesonide and formoterol differentially modulate the expression of C/EBP-alpha and calreticulin in airway smooth muscle (ASM) cells
Source: Eur Respir J 2006; 28: Suppl. 50, 756s
Year: 2006

CRE, but not AP-1, NF-κB, or C/EBP, mediates β-agonist-induced IL-6 gene expression induced in human airway smooth muscle (HASM) cells
Source: Eur Respir J 2001; 18: Suppl. 33, 407s
Year: 2001

Glutathionylation of IκB-α inhibits NF-κB dependent chemokine secretion in airway smooth muscle cells
Source: Annual Congress 2010 - Regulation of airway pharmacology
Year: 2010

17-beclomethasone monopropionate or inhibition of MAPK p38 signalling abolish IL-8 release stimulated by cigarette smoke extract or acrolein in normal human airway smooth muscle cells
Source: Annual Congress 2010 - Airway smooth muscle cells
Year: 2010


Beta2-agonists but not glucocorticoids inhibit proliferation of asthmatic airway smooth muscle cells
Source: Eur Respir J 2004; 24: Suppl. 48, 251s
Year: 2004

Increased secretion of leukaemia inhibitory factor by immature airway smooth muscle cells enhances intracellular signalling and airway contractility
Source: Eur Respir J 2006; 28: Suppl. 50, 260s
Year: 2006

Effect of p21Ras intervention on the phenotype of airway smooth muscle cells from asthmatic rats
Source: Annual Congress 2010 - Airway smooth muscle cells
Year: 2010


Expression of GATA family of transcription factors in T-cells, monocytes and bronchial biopsies
Source: Eur Respir J 2001; 18: 466-473
Year: 2001



Impaired inhibitory action of corticosteroids on chemokine expression induced by TNFalpha in airway smooth muscle (ASM) cells from patients with severe asthma
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013