Decrease of physical capacity during acute induction at high altitude is associated with more pronounced increased pulmonary arterial pressure
A. Sarybaev, A. Maripov, A. Akunov, U. Shermatov, D. Majumdar, S. B. Singh (Bishkek, Kyrgyzstan; Delhi, India)
Source: Annual Congress 2012 - Various issues in clinical physiology
Session: Various issues in clinical physiology
Session type: Thematic Poster Session
Number: 3786
Disease area: Pulmonary vascular diseases
Abstract The aim is to assess the relation between physical performance (max VO2) and systolic pulmonary arterial pressure (sPAP) at high altitude (HA). Subjects and methods. Twenty one subjects aged from 18 to 30 years were examined. After being examined at the low altitude (Bishkek, 700 m above sea level) all subject were transported at 3200 m. At the HA patients were repeatedly examined in the 7th, 14th and 21st days of the sojourning, as well as on the 3rd day after coming down to Bishkek. Results. The subjects were divided into two groups: the 1st group - ²normoresponders² (n=14), subjects, whose sPAP was up to 35 mmHg in the first days at HA and the 2nd group - ²hyperresponders² (n=7), subjects with sPAP 35 mmHg or higher. Results are shown.
Comparison of maxVO2 between normo- and hyperresponders Group Bishkek HA-7 HA-14 HA-21 Descent Normoresponders 43,7±1,7 40,4±1,1 41,0±1,6 41,6±1,9 46,5±1,7 Hyperresponders 45,8±1,2 38,8±1,5* 42,4±2,5 44,1±2,8 48,4±3,0
max VO2 – maximal oxygen consumption, ml/min/kg, * - p < 0,05 between max VO2 in Bishkek and at the 7th days of high altitude staying At Bishkek the 1st group had the higher max VO2 value, but after the ascent at HA the max VO2 significantly decreased at that group (from 45,8 to 38,8 ml/min/kg, p< 0,01), while the 2nd group demonstrated the nonsignificant max VO2 reduction. Later these differences disappeared. Obtained data can denote the presence of the interrelation between sPAP response to HA hypoxia and decrease of the physical capacity at HA. This supposition should be tested on a larger sample of volunteers.
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A. Sarybaev, A. Maripov, A. Akunov, U. Shermatov, D. Majumdar, S. B. Singh (Bishkek, Kyrgyzstan; Delhi, India). Decrease of physical capacity during acute induction at high altitude is associated with more pronounced increased pulmonary arterial pressure. Eur Respir J 2012; 40: Suppl. 56, 3786
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