Subcutaneuous injection of monoclonal antibody anti-DEC205 conjugated with ovalbumin atenuates allergic lung inflammation of animals previously sensitized to allergen

A.P. Ligeiro de Oliveira, E. Rampazo, E. Gomes, M. Yamamoto, S. Boscardin, M. Russo (Sao Paulo, Brazil)

Source: Annual Congress 2012 - Mechanisms and modulation of allergic inflammation in the lung
Session: Mechanisms and modulation of allergic inflammation in the lung
Session type: Thematic Poster Session
Number: 2331
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
A.P. Ligeiro de Oliveira, E. Rampazo, E. Gomes, M. Yamamoto, S. Boscardin, M. Russo (Sao Paulo, Brazil). Subcutaneuous injection of monoclonal antibody anti-DEC205 conjugated with ovalbumin atenuates allergic lung inflammation of animals previously sensitized to allergen. Eur Respir J 2012; 40: Suppl. 56, 2331

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Effects of anti-M1 prime monoclonal antibody, MEMP1972A following allergen challenge in patients with mild asthma
Source: Annual Congress 2012 - New bronchodilators and other novel drugs for asthma and COPD
Year: 2012

CAT-354, an IL-13-neutralising human monoclonal antibody, inhibits airways hyperresponsiveness and eosinophilia in a cynomolgus monkey model of allergen challenge
Source: Eur Respir J 2005; 26: Suppl. 49, 232s
Year: 2005

MEMP1972A, an anti-M1 prime monoclonal antibody, reduces serum IgE in healthy and allergic rhinitis subjects
Source: Annual Congress 2012 - The best of pharmacology treatment for asthma and COPD
Year: 2012

Immunomodulation of the allergic airway inflammation by allergen DNA targeted receptors for the Fc region on dendritic cells in mice sensitized/challenged by OVA allergen
Source: Annual Congress 2007 - Mouse models of allergic airway inflammation
Year: 2007


Effect of humanized monoclonal anti-IgE antibody, omalizumab, on allergen challenge-induced nasal response in subjects with allergic rhinitis and allergic asthma
Source: Eur Respir J 2001; 18: Suppl. 33, 36s
Year: 2001

The effects of efalizumab, an anti-CD11a monoclonal antibody (hu1124), on allergen-induced airway inflammation in atopic asthmatic subjects
Source: Eur Respir J 2001; 18: Suppl. 33, 350s
Year: 2001

Anti-CD25 antibody daclizumab reduces airway eosinophilia induced by ascaris suum challenge in atopic monkeys
Source: Annual Congress 2008 - Novel experimental approaches to understanding asthma and COPD II
Year: 2008

A monoclonal antibody to IL-1B attenuates the late asthmatic response to antigen challenge in patients with mild asthma
Source: Annual Congress 2006 - Novel treatments for asthma
Year: 2006


Treatment with omalizumab (rhuMAb-E25), a monoclonal anti-IgE antibody induces effective changes in subjects with allergic asthma
Source: Eur Respir J 2001; 18: Suppl. 33, 37s
Year: 2001

Endotoxin potentiates allergic airway inflammation in ovalbumin sensitised and challenged mice
Source: Annual Congress 2009 - Animal models of airways inflammation
Year: 2009

Intratracheal instillation of antigen-specific IgG ameliorated murine bronchial asthma via reduction of antigen presentation of airway dendritic cells
Source: Annual Congress 2008 - Understanding allergic airway inflammation with the help of animal models
Year: 2008


The rationale for treating allergic asthma with anti-IgE
Source: Eur Respir Rev 2007; 16: 61-66
Year: 2007



Suboptimal treatment response to anti-IL-5 monoclonal antibodies in severe eosinophilic asthmatics with airway autoimmune phenomena
Source: Eur Respir J, 56 (4) 2000117; 10.1183/13993003.00117-2020
Year: 2020



Anti-IL-5 antibody reduces the increase of CD34+ eosinophils in a mouse model of airway allergic eosinophilia
Source: Eur Respir J 2002; 20: Suppl. 38, 28s
Year: 2002

Evaluation of bronchial hyperreactivity and other functional parameters in severe asthma patients treated with anti-interleukin-5 monoclonal antibody (IL5)
Source: International Congress 2019 – Real-world experience of monoclonal antibodies in asthma
Year: 2019

Induction of allergic bronchial hyperreactivity in DA-rats despite low-level eosinophilia in airways and lack of specific IgE antibodies
Source: Annual Congress 2007 - Mouse models of allergic airway inflammation
Year: 2007


Up-regulation of chemically-induced but not mechanically-induced cough during early-phase response to allergen inhalation in ovalbumin sensitized rabbits.
Source: International Congress 2017 – Animal models of asthma and allergies
Year: 2017

Intratracheal instillation of anti-CD103 does not affect allergic airway inflammation in a mouse asthma model
Source: Eur Respir J 2005; 26: Suppl. 49, 25s
Year: 2005

Tolerability assessment of a recombinant humanized monoclonal anti-IgE antibody (omalizumab) as a treatment for seasonal allergic rhinitis
Source: Eur Respir J 2002; 20: Suppl. 38, 116s
Year: 2002

Cross-reactive antibodies against dust mite-derived enolase induce neutrophilic airway inflammation
Source: Eur Respir J, 57 (1) 1902375; 10.1183/13993003.02375-2019
Year: 2021