Source: Annual Congress 2012 - Prognostic indices in respiratory infections
Disease area: Airway diseases, Respiratory infections

Abstract

46 COPD exacerbation patients were examined. Cytological research of brush-biopsies were taken at bronchoscopy was made; for verification of infectional nature of COPD exacerbation the quantitative bacteriological sputum research, definition of diagnostic main IgG, IgM levels to Ch.pneumoniae, M.pneumoniae in serum by means immuno-assay method, definition of their genomes fragments in sputum by means of PCR method were made. Kruskal – Wallis criterion was used.
Infectional character of COPD exacerbation was confirmed at 36 patients. Typical cells count in H.influenzae, Ch.pneumoniae, M.pneumoniae infection was 14.6±2.2%, 15.1±2.5%, 15.5±3.1%, that was reliable low (p<0.05), than in S.pneumoniae, M.catarrhalis infection (32.6±3.6%, 37.1±5.1%). Reserved cells count was reliable high (p<0.05) in M.pneumoniae (12.0±2.6%), than S.pneumoniae H.influenzae, Ch.pneumoniae, M.catarrhalis infection (5.3±1.0%, 8.4±1.5%, 8.9±1.9%, 5.0±2.3%). Squamus metaplased cells was reliable high (p<0.05) in H.influenzae, Ch.pneumoniae, M.pneumoniae infection (6.3±1.2%, 7.5±1.2%, 7.4±1.6%), than in S.pneumoniae, M.catarrhalis infection (2.5±0.9%, 2.2±0.7%). Dystrophical cells count was reliable high (p<0.05) in H.influenzae, Ch.pneumoniae infection (56.6±2.1%, 54.9±2.8%), than S.pneumoniae, M.pneumoniae M.catarrhalis infection (46.9±3.0%, 44.7±3.5%, 38.9±4.3%). Macrophages quantity was reliable high (p<0.05) in M.pneumoniae infection (55.1±0.9%) as compared with S.pneumoniae H.influenzae, Ch.pneumoniae, M.catarrhalis infection (33.7±3.7%, 27.4±3.0%, 25.2±3.5%).
Infectional agent species influence on degree of bronchial mucosa damage. H.influenzae, Ch.pneumoniae have more injured effects and M.catarrhalis have least injured effects.

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Citations should be made in the following way:
S. Nesterovich, E. Bukreeva (Tomsk, Russian Federation). Cellular composition of bronchial brush-biopsies at COPD exacerbation. Eur Respir J 2012; 40: Suppl. 56, 2530

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