Source: Annual Congress 2012 - Various issues in clinical physiology
Disease area: Airway diseases

Abstract

Introduction: Heart rate recovery (HRR) after maximal exercise is a marker of autonomic cardiac dysfunction (ACD) in Chronic Obstructive Pulmonary Disease (COPD). But it has not been evaluated HRR immediately after 6 minute walking test (6MWT) on this population. Our objective was to evaluate the kinetics of the HRR curve (HRRk).
Methods: We measured HRRk during 4 minutes after the 6MWT in 24 COPD patients (70 ± 6 years, mean ± SD, FEV1 54 ± 17%) and 19 healthy subjects (68 ± 10 years, FEV1 87 ± 7%). To facilitate the comparison among groups and remove the effect of different peak HR, the HRR curves were normalized to a range of 1 at peak heart rate (HRpeak) and zero at 4 minutes into recovery (HRR4).
Results: We found differences at rest on HR (82 ± 13 vs 72 ± patients in healthy 12 beats, p = 0.017), HRR (HRR1 = 14 ± 7 vs in patients and 21 ± 8 beats in healthy subjects, p = 0.003) and 6MWT (516 ± 79 vs patients 578 ± 84 meters healthy, p = 0.018). The slope of the standard and normalized curves were significantly lower in patients with COPD (k= 0.08 in COPD patients vs k = 1.48 in healthy subjects, p = 0.017).

Conclusions: In COPD patients HRRk was lower than healthy subjects after 6MWT. This abnormality is reflected from HRR1. 6MWT may be a simple test to detect ACD in COPD.

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D.A. Rodriguez, A. Arbillaga, E. Kortianou, J. Alison, A. Casas, S. Giavedoni, A. Barberán, J. Vilaró, I. Vogiatzis, R. Rabinovich, E. Gimeno, J. Roca (Barcelona, Spain; Athens, Greece; Sydney, Australia; Bogota, Colombia; Edinburgh, United Kingdom). Autonomic cardiac dysfunction in COPD: The role of 6MWT. Eur Respir J 2012; 40: Suppl. 56, 3799

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