Source: Annual Congress 2012 - Prognostic indices in respiratory infections
Disease area: Airway diseases, Respiratory infections

Abstract

46 COPD exacerbation patients were examined. Cytological research of brush-biopsies were taken at bronchoscopy was made; for verification of infectional nature of COPD exacerbation the quantitative bacteriological sputum research, definition of diagnostic main IgG, IgM levels to Ch.pneumoniae, M.pneumoniae in serum by means immuno-assay method, definition of their genomes fragments in sputum by means of PCR method were made. Kruskal – Wallis criterion was used.
Infectional character of COPD exacerbation was confirmed at 36 patients. Inflammatory cells composition in bronchial brush-biopsy were researched. Macrophages quantity was reliable high (p<0.05) in M.pneumoniae infection (55.1±0.9%) as compared with S.pneumoniae H.influenzae, Ch.pneumoniae, M.catarrhalis (33.7±3.7%, 27.4±3.0%, 25.2±3.5%; 36,2±4,9% accordingly). Neutrophiles count was reliable high (p<0.05) in H.influenzae, Ch.pneumoniae (50.3±4.5%, 56.5±4.2% accordingly) as compared with S.pneumoniae, M.pneumoniae M.catarrhalis (36.1±4.0%, 30.8±4.7%, 34.8±4.6% accordingly). Eosinophiles count was reliable high in S.pneumoniae infection (3.7±1.4%) as compared with H.influenzae, Ch.pneumoniae, M.pneumoniae, M.catarrhalis (3,0±1,5%; 2,0±1,1%; 1,2±0,1%; 1,4±0,6% accordingly) (p<0.05).
Infectional agent species influence on intensification and character of inflammation in bronchial mucosa in COPD exacerbation. M.pneumoniae induces mononuclear response, H.influenzae, Ch.pneumoniae induces polymorphonuclear response.

Rating:

Share or cite this content

Citations should be made in the following way:
S. Nesterovich, E. Bukreeva (Tomsk, Russian Federation). Inflammatory cells composition of bronchial brush-biopsies in dependence on infectional agent species at COPD exacerbation. Eur Respir J 2012; 40: Suppl. 56, 2531

Member's Comments

No comment yet.

Related content which might interest you: Bronchial brush-biopsies cells in dependence on infectional agent species at COPD exacerbation Source: Annual Congress 2010 - Colonisation and infection in COPD Year: 2010 Bronchial brush-biopsies cells in dependence on infectional agent species at COPD exacerbation Source: Annual Congress 2011 - Role of infection in exacerbations of COPD Year: 2011 Composition of bronchial brush-biopsies in dependence on infectional agent species at COPD exacerbation Source: Annual Congress 2008 - Microbiology and treatment of bronchiectasis and exacerbations of COPD Year: 2008 Cellular peculiarities of bronchial brush-biopsies in dependence on infectional agent species at COPD exacerbation Source: Annual Congress 2009 - Exacerbations of COPD and bronchiectasis: aetiology and treatment Year: 2009 Cells composition of brush-biopsies in dependence on infectional agent species at COPD exacerbation Source: Eur Respir J 2004; 24: Suppl. 48, 408s Year: 2004 Bronchial brush-biopsies peculiarities in dependence on different pathogens at COPD exacerbation Source: Eur Respir J 2006; 28: Suppl. 50, 4s Year: 2006 Cellular composition of bronchial brush-biopsies at COPD exacerbation Source: Annual Congress 2012 - Prognostic indices in respiratory infections Year: 2012 Composition of bronchial brush-biopsies at different etiology of COPD exacerbation Source: Annual Congress 2010 - Colonisation and infection in COPD Year: 2010 Chronic sputum production and airway inflammation in COPD in the stable state and at exacerbation Source: Eur Respir J 2005; 26: Suppl. 49, 442s Year: 2005 Cellular composition of bronchial brush-biopsies in dependence on smoking and etiology of COPD exacerbation Source: Eur Respir J 2007; 30: Suppl. 51, 403s Year: 2007 Bronchial brush-biopsies composition at COPD exacerbation Source: Eur Respir J 2006; 28: Suppl. 50, 734s Year: 2006 Bronchial wall inflammatory cells and signs of remodeling in COPD and asthma Source: International Congress 2019 – Immunopathological mechanisms of lung disease Year: 2019 Inflammatory mediators in eosinophilic COPD phenotype and asthma with fixed airflow obstruction Source: International Congress 2018 – Understanding the immunopathology that underlies airway obstructive diseases Year: 2018 Effects of inhaled corticosteroids on airway inflammations of different types in patients with chronic obstructive pulmonary disease or asthma in stable phase Source: Annual Congress 2009 - Aspects of clinical asthma Year: 2009 Inflammatory cell phenotypes in bronchial asthma Source: Eur Respir J 2005; 26: Suppl. 49, 484s Year: 2005 Differential response of COPD bronchial epithelium to LPS in a three-dimensional culture model Source: Annual Congress 2006 - Airway epithelial cells in inflammation Year: 2006 Airway epithelial inflammatory responses and clinical parameters in COPD Source: Eur Respir J 2003; 22: 94-99 Year: 2003 Viral and bacterial etiology of severe COPD exacerbations: relationship with airway inflammation Source: Eur Respir J 2005; 26: Suppl. 49, 251s Year: 2005 Peculiarities of brush-biopsies of bronchial mucosa at different aetiology of COPD exacerbation Source: Annual Congress 2009 - Exacerbations of COPD and bronchiectasis: aetiology and treatment Year: 2009 Bronchial limitation and infectional pathogens in COPD exacerbation Source: Eur Respir J 2006; 28: Suppl. 50, 4s Year: 2006