Factors predicting exercise-induced oxygen desaturation in stable COPD
K. Hussein, A. Farouk Alkarn, S. Hamdi, R. El-Sokkary, H. Shams (Assiut, Egypt)
Source: Annual Congress 2012 - Exercise capacity: from elite athletes to severe impairment
Session: Exercise capacity: from elite athletes to severe impairment
Session type: Thematic Poster Session
Number: 839
Disease area: Airway diseases, Pulmonary vascular diseases
Abstract Background and objective:- Some resting pulmonary function and blood gas parameters might predict exercise-induced oxygen desaturation in patients with stable COPD. We aimed at studying these factors.Patients and methods:- We tested 55 patients with stable COPD (FEV1 /FVC%: 54.31). Resting pulmonary function, arterial blood gases, echocardiography, and incremental cardiopulmonary exercise testing were done for all patients. We diagnosed exercise-induced oxygen desaturation if O2 saturation decreased ≥ 4% with exercise. We compared desaturated (DS) with non-desaturated (NDS) patients.Results:- Exercise induced oxygen desaturation (DS) occurred in 28 subjects while 27 were non-desaturated (NDS). FEV1 % of predicted was significantly lower in DS (33.75±9.28) than NDS patients (49.49±19.86, P<0.001). Diffusing capacity DLCO % predicted was significantly lower in DS (47.54±20.25) than NDS (67.35±19.62, P<0.001). Resting O2 saturation SaO2 % was significantly lower in DS (91.9±2.88) than NDS patients (95.94±2.9, P<0.001). Resting PaCO2 mmHg was significantly higher in DS (63.46±11.58) than NDS patients (38.97±6.38, P<0.001). Pulmonary artery systolic pressure mmHg was significantly higher in DS (42.21±11.90) than NDS (34.15±12.14, P< 0.01). Medical Research Council MRC dyspnea score was significantly higher in DS (3.54±0.69) than NDS patients (2.44±0.97, P<0.001). On the other hand, there were no statistically significant differences in FEV1 /FVC%, total lung capacity, residual volume, and resting heart rate between the DS and NDS patients.Conclusion:- FEV1 %, DLCO, resting SaO2 , resting PaCO2 , pulmonary artery systolic pressure and MRC dyspnea score can predict exercise-induced desaturation in stable COPD.
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K. Hussein, A. Farouk Alkarn, S. Hamdi, R. El-Sokkary, H. Shams (Assiut, Egypt). Factors predicting exercise-induced oxygen desaturation in stable COPD. Eur Respir J 2012; 40: Suppl. 56, 839
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