Source: Annual Congress 2012 - Prognostic indices in respiratory infections
Disease area: Airway diseases, Respiratory infections

Abstract

Background: Pseudomonas aeruginosa is found in COPD patients sputum in 4-15%, mainly in those with advanced disease and / or in pthose requiring mechanical ventilation. Currently, there are no data to justify an empiric antibiotic therapy against Pseudomonas aeruginosa when a new COPD exacerbation occurs in a patient with a previous Pseudomonas aeruginosa exacerbation.
Methods: We conducted a retrospective study to analyse microbialogical ecology exacerbations in COPD patients with at least one Pseudomonas aeruginosa exacerbation
Results: Among the 243 COPD patients hospitalized during the study period (2007-2011), only 23 (9.5%) had at least one Pseudomonas aeruginosa exacerbation (between 1 and 11 exacerbations per patient). They presented a new Pseudomonas aeruginosa exacerbation in 54% of cases. From one to an other exacerbation, the Pseudomonas aeruginosa susceptibility changed, with a wild type Pseudomonas aeruginosa in 58% of cases during the first exacerbation and 42% during the next one. COPD patients with GOLD stage IV were rarely hospitalized for a wild Pseudomonas aeruginosa exacerbation (p = 0.01, 15% vs.83% in GOLD stage II and III patients)
Conclusion: In this pilot study, the microbialogical ecology of COPD exacerbation differed from one exacerbation to another, contrary to that observed in cystic fibrosis patients.

Rating:

Share or cite this content

Citations should be made in the following way:
I. Rault, V. Jounieaux, C. Andrejak (Amiens, France). Pseudomonas aeruginosa exacerbations in COPD patients. Eur Respir J 2012; 40: Suppl. 56, 2522

Member's Comments

No comment yet.

Related content which might interest you: Etiology of exacerbations in severe COPD patients with bronchial chronic colonization by pseudomonas Source: Annual Congress 2013 –Difficult and rare respiratory infections Year: 2013 COPD and pseudomonas aeruginosa, an association Source: International Congress 2014 – Resistance, bacteriological profile and comorbidities in respiratory infections Year: 2014 Influence of biofim on the bronchial microbiome in COPD patients colonized or infected by pseudomonas aeruginosa Source: International Congress 2015 – Advances from translational research in respiratory infections Year: 2015 Helicobacter pylori infection in COPD Source: Annual Congress 2010 - Various aspects of respiratory epidemiology Year: 2010 Presence of pneumocystis jiroveci colonization in patients with COPD Source: Annual Congress 2011 - Role of infection in exacerbations of COPD Year: 2011 Acute exacerbations of COPD due to pseudomonas aeruginosa: Impact of antimicrobial resistance Source: International Congress 2015 – Infection in COPD: different aspects of the host/pathogen balance Year: 2015 Pseudomonas aeruginosa in patients hospitalised for COPD exacerbation: a prospective study Source: Eur Respir J 2009; 34: 1072-1078 Year: 2009 Pseudomonas aeruginosa and antibiotic resistance in acute exacerbations of COPD (AECOPD) Source: Annual Congress 2009 - Respiratory infection caused by Pseudomonas aeruginosa Year: 2009 Heliox administration in patients with COPD exacerbation – Technical aspects Source: Annual Congress 2010 - Mechanical ventilation and weaning Year: 2010 Survival in COPD patients with hospitalization due to exacerbation Source: International Congress 2014 – Longitudinal studies of respiratory disease Year: 2014 Efficacy of administration of 0.02% solution of decamethoxine via nebulizer in patients with infectious exacerbations of COPD Source: Annual Congress 2013 –COPD treatment Year: 2013 Characterization of readmissions in patients hospitalized with COPD exacerbation Source: International Congress 2016 – Novel avenues in the treatment of COPD II Year: 2016 Impact of bronchiectasis on duration of hospitalization in patients with exacerbations of COPD Source: International Congress 2015 – Asthma and COPD: overlap and exacerbations Year: 2015 Severe exacerbations of chronic obstructive pulmonary disease (COPD) due to Pseudomonas aeruginosa: resistance to common antibiotics Source: Eur Respir J 2001; 18: Suppl. 33, 540s Year: 2001 Pseudomonas aeruginosa drug susceptibility in patients hospitalized with COPD exacerbation and bronchiectasis Source: Eur Respir J 2001; 18: Suppl. 33, 541s Year: 2001 Effect of lower airway bacterial colonisation on time to acute exacerbation in patients with COPD Source: International Congress 2015 – COPD: exacerbations, gas exchange and associated dysfunction Year: 2015 Comorbidities associated with chronic obstructive pulmonary disease (COPD) – A clinical study Source: Annual Congress 2011 - COPD diagnosis Year: 2011 Predictors of PAO2 and PaCO2 in COPD patients Source: Annual Congress 2009 - Gas exchange and exercise in respiratory diseases Year: 2009 Symptoms experienced by COPD patients during exacerbations and their association with healthcare utilization – EXACO study Source: Annual Congress 2011 - Respiratory epidemiology: quality of life, therapy and socioeconomics Year: 2011 Identification of nasal virus infection in patients with COPD exacerbations Source: International Congress 2014 – COPD: points to ponder Year: 2014