Source: Annual Congress 2004 - New developments in endobronchial treatment
Disease area: Thoracic oncology

Abstract

OBJECTIVE : to evaluate the use of topical mithomycin-C ( Mit-C ) in the prevention of tracheal restenoses.DESIGN: prospective, experimental, longitudinal. PATIENT SELECTION : patients presenting with benign tracheal stenoses.TIME : march 2001 – july 2003. DEFINITIONS : The procedure was considered succesful if the patient presented resolution of symptoms and endoscopic improvement, partial success if one of the two aspects was achieved, and failure the persistence of symptoms and stenoses. PROCEDURES : Tracheal stenoses was treated with laser o mechanical dilatation. Mit-C was applied topically ( 0.25mgr/ml. ) during 5 minutes. Patients were treated with antibiotics for seven days and budesonide 1600 mcgr/ day for three months. RESULTS : Eight patients were included , mean age of 35.8 years ( 17 – 56 ). Tracheal stenoses was secondary to tracheal intubation ( 7 patients ) and Wegeners Granulomatosis. Lesions had a mean length of 3.8 cms ( 1.5 - 6 cms ), and mean diameter was 5.1 mm ( 4 – 9 mm ); they had been present for 1 – 48 months ( mean 24.3 months ). In five patients the use of Mit-C was succesful, achieving symptom control, lesion stability and allowing the removal of stents in two cases. Patients remained asymptomatic for over a year ( mean follow up 14.5 months ). Three patients presented airway restenoses.CONCLUSIONS: The use of Mit - C can mantain airway patency after laser or mechanical dilation and achieve lesion stability, preventing restenoses or the need for stent placement, especially in patients who are unable to undergo surgery. Further studies are needed to draw definitive conclusions on its use.

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Citations should be made in the following way:
D. Mrad, M. Diaz, J. Rolleri (Buenos Aires, Argentina). Mithomycin – C in the prevention of tracheal restenoses. Eur Respir J 2004; 24: Suppl. 48, 4295

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