Source: Annual Congress 2004 - New developments in endobronchial treatment
Disease area: Thoracic oncology

Abstract

Objective: to investigate the efficacy and long term results of PDT in a subset of patients with lung cancer with disease limited to bronchial wall and lumen.
Material & Methods: 16 patients amongst 207 undergoing bronchoscopic PDT for lung cancer. All patients had standard investigation, work up and staging procedure as well as assessment of bronchoscopic extent of the endoluminal lesion. PDT method was intravenous injection of 2mg/kg/bw of Photofrin followed 24-72 hours later by bronchoscopic illumination for 150-200 joules/cm. Results were assessed by review and bronchoscopy at 5-6 weeks post PDT and at regular intervals in follow up clinic until death.
Results:16 subjects (10 male 6 female) aged 53-74 (mean 65.2) received 26 treatments. 7 patients had previous treatment (including 3 resections) with curative intent. In these PDT was given for local recurrence. There was no operative mortality. 1 patient developed mild skin photosensitivity. Every patient had a period of complete response 6-24 months. 7 patients have died. Their survival was from 2-103 months (mean 55.9). 9 are alive from 6-36 months (mean 21.6). Mean & median survival for the whole group was 64 ± 10 m & 77 ± 9 m respectively.
Conclusion: Bronchoscopic PDT appears to be an effective therapeutic method in patients with cancer limited to endobronchial lesions. In this subset long survival can be expected provided there is no extra bronchial dissemination.

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Citations should be made in the following way:
K. Moghissi, K. Dixon, A. C. Thorpe, C. Oxtoby (Goole, United Kingdom). Photodynamic therapy (PDT) in lung cancer with disease limited to endobronchial lesions. Eur Respir J 2004; 24: Suppl. 48, 4292

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